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ProSci Inc.
Numéro de catalogue:
(PRSI29-746)
Fournisseur:
ProSci Inc.
Description:
The function remains unknown.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-540)
Fournisseur:
ProSci Inc.
Description:
Anti-PTGER4 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-499)
Fournisseur:
ProSci Inc.
Description:
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) is a 45-50 kDa macrophage-specific transmembrane glycoprotein that belongs to the B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type I g domain. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages. No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases. Human VSIG4 is 399 amino acids (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20 - 283) and a 95 aa cytoplasmic region.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-501)
Fournisseur:
ProSci Inc.
Description:
Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXP-5200BT)
Fournisseur:
ProSci Inc.
Description:
IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-502)
Fournisseur:
ProSci Inc.
Description:
Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-680)
Fournisseur:
ProSci Inc.
Description:
PPM1M belongs to the PP2C family. It contains 1 PP2C-like domain. The exact function of PPM1M is not known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-623)
Fournisseur:
ProSci Inc.
Description:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-046)
Fournisseur:
ProSci Inc.
Description:
ZFP64 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 9 C2H2-type zinc fingers and may be involved in transcriptional regulation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-334)
Fournisseur:
ProSci Inc.
Description:
Anti-NFE2L2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-333)
Fournisseur:
ProSci Inc.
Description:
Anti-Alk Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-323)
Fournisseur:
ProSci Inc.
Description:
Anti-BCL2L15 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4003)
Fournisseur:
ProSci Inc.
Description:
APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4409P)
Fournisseur:
ProSci Inc.
Description:
IPR1 peptide is used for blocking the activity of IPR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-001)
Fournisseur:
ProSci Inc.
Description:
SSBP3 may be involved in transcription regulation of the alpha 2 (I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-987)
Fournisseur:
ProSci Inc.
Description:
SAMHD1 contains 1 HD domain and 1 SAM (sterile alpha motif) domain. SAMHD1 may play a role in mediating proinflammatory responses to TNF-alpha signaling.
UOM:
1 * 50 µG
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