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ProSci Inc.
Numéro de catalogue:
(PRSI79-610)
Fournisseur:
ProSci Inc.
Description:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXG-6133)
Fournisseur:
ProSci Inc.
Description:
Anti-GHRL Chicken Polyclonal Antibody
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI79-603)
Fournisseur:
ProSci Inc.
Description:
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-622)
Fournisseur:
ProSci Inc.
Description:
a maternal imprinting gene. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal (Meg3p), contains exons 1-3. The second form, Meg3-distal (Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXG-6156)
Fournisseur:
ProSci Inc.
Description:
Anti-CXADR Chicken Polyclonal Antibody
UOM:
1 * 500 µG
Numéro de catalogue:
(PRSIXG-6130)
Fournisseur:
ProSci Inc.
Description:
Anti-APP Chicken Polyclonal Antibody
UOM:
1 * 500 µG
Numéro de catalogue:
(PRSIXG-6165)
Fournisseur:
ProSci Inc.
Description:
Anti-KCNE2 Chicken Polyclonal Antibody
UOM:
1 * 500 µG
Numéro de catalogue:
(PRSI79-642)
Fournisseur:
ProSci Inc.
Description:
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-629)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-641)
Fournisseur:
ProSci Inc.
Description:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXPS-1005)
Fournisseur:
ProSci Inc.
Description:
DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSIXG-6194)
Fournisseur:
ProSci Inc.
Description:
Anti-HSPA13 Chicken Polyclonal Antibody
UOM:
1 * 500 µG
Numéro de catalogue:
(PRSIXG-6174)
Fournisseur:
ProSci Inc.
Description:
Anti-FABP4 Chicken Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSIXG-6175)
Fournisseur:
ProSci Inc.
Description:
Anti-CRP Chicken Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI79-647)
Fournisseur:
ProSci Inc.
Description:
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-693)
Fournisseur:
ProSci Inc.
Description:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
UOM:
1 * 1 EA
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