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ProSci Inc.
Numéro de catalogue:
(PRSI79-368)
Fournisseur:
ProSci Inc.
Description:
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-373)
Fournisseur:
ProSci Inc.
Description:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-347)
Fournisseur:
ProSci Inc.
Description:
ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the ζ chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-ζ chain, which can mediate the transduction of extracellular stimuli into cellular effector functions
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-357)
Fournisseur:
ProSci Inc.
Description:
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3873P)
Fournisseur:
ProSci Inc.
Description:
Bfl-1 peptide is used for blocking the activity of Bfl-1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3847P)
Fournisseur:
ProSci Inc.
Description:
MD-1 peptide is used for blocking the activity of MD-1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-644)
Fournisseur:
ProSci Inc.
Description:
NIX1 holds two copies of the LXXLL motif. NIX1 displays a neuronal specific expression pattern. It selectively interacts with distinct nuclear receptors of the RAR and TR subfamily, but does not bind steroid hormone receptors. By docking to activated nuclear receptors in an AF2-D-dependent fashion, NIX1 might displace coactivators and result in suppression of the transcriptional activity of liganded nuclear receptors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-397)
Fournisseur:
ProSci Inc.
Description:
Anti-Vaccinia virus Rabbit Polyclonal Antibody
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI28-030)
Fournisseur:
ProSci Inc.
Description:
ASPH is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3871P)
Fournisseur:
ProSci Inc.
Description:
BAG-1 peptide is used for blocking the activity of BAG1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-400)
Fournisseur:
ProSci Inc.
Description:
Anti-Vaccinia virus Rabbit Polyclonal Antibody (Biotin)
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI92-040)
Fournisseur:
ProSci Inc.
Description:
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1CC may play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4551)
Fournisseur:
ProSci Inc.
Description:
Unc93a Antibody: Unc93a, a human homolog of the C. elegans Unc93 gene, was initially identified by the sequencing of chromosome 6q27 at D6S193 as loss at this region correlated with sporadic ovarian cancer. Further analysis however, showed no tumor suppressor role for Unc93a. Unlike Unc93b, another homolog of the C. elegans Unc93 gene that is crucial for Toll-like receptor (TLR) signaling, the function of Unc93a is unknown. It is expressed in testis, small intestine, spleen, prostate and ovary.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4559)
Fournisseur:
ProSci Inc.
Description:
CAPS1 Antibody: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-873)
Fournisseur:
ProSci Inc.
Description:
ETV5 Contains 1 ETS DNA-binding domain and belongs to the ETS family. The ETV5 gene expression is regulated by the conventional PKC (cPKC) pathway.ETV5 is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity Phosphorylated ETV5 and the actin cytoskeleton regulate CD44-mediated hyaluronan binding in myeloid cells. ERMs (ezrin/radixin/moesin) function as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases. ETV5 can cooperate with c-Jun and has a role in progression of breast cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-188)
Fournisseur:
ProSci Inc.
Description:
Anti-SUMF1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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