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ProSci Inc.
Numéro de catalogue:
(PRSI42-340)
Fournisseur:
ProSci Inc.
Description:
Anti-TPH2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXP-5157)
Fournisseur:
ProSci Inc.
Description:
IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-889)
Fournisseur:
ProSci Inc.
Description:
The function remains unknown.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-144)
Fournisseur:
ProSci Inc.
Description:
homeobox protein GSH-2
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-153)
Fournisseur:
ProSci Inc.
Description:
GLIS3 is a member of the GLI-similar zinc finger protein family and has five C2H2-type zinc finger domains. GLIS3 functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-161)
Fournisseur:
ProSci Inc.
Description:
ZNF488 is a candidate transcription factor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3471)
Fournisseur:
ProSci Inc.
Description:
Caspase-6 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was idientifed based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3473)
Fournisseur:
ProSci Inc.
Description:
Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3639P)
Fournisseur:
ProSci Inc.
Description:
TLR1 peptide is used for blocking the activity of TLR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-312)
Fournisseur:
ProSci Inc.
Description:
Anti-Listeria Rabbit Polyclonal Antibody (Biotin)
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI7277P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the center of human SHISA4.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-590)
Fournisseur:
ProSci Inc.
Description:
Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6891)
Fournisseur:
ProSci Inc.
Description:
LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6915)
Fournisseur:
ProSci Inc.
Description:
TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6913)
Fournisseur:
ProSci Inc.
Description:
PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI7265P)
Fournisseur:
ProSci Inc.
Description:
18 amino acid peptide near the amino terminus of human SDPR.
UOM:
1 * 50 µG
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