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ProSci Inc.
Numéro de catalogue:
(PRSI46-729)
Fournisseur:
ProSci Inc.
Description:
Anti-PCSK6 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI50-174)
Fournisseur:
ProSci Inc.
Description:
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI50-180)
Fournisseur:
ProSci Inc.
Description:
The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
UOM:
1 * 50 µl
Numéro de catalogue:
(PRSI50-151)
Fournisseur:
ProSci Inc.
Description:
Anti-CALCA Mouse Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI46-745)
Fournisseur:
ProSci Inc.
Description:
Anti-LTF Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-234)
Fournisseur:
ProSci Inc.
Description:
RNF113B contains 1 RING-type zinc finger and 1 C3H1-type zinc finger and the function remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-663)
Fournisseur:
ProSci Inc.
Description:
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXPS-1029)
Fournisseur:
ProSci Inc.
Description:
TAO (thousand and one amino acid) protein kinases mediate signaling from carbachol to p38 MAPK and ternary complex transcription factors. This has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs. Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI46-655)
Fournisseur:
ProSci Inc.
Description:
Anti-ESRRG Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-889)
Fournisseur:
ProSci Inc.
Description:
Anti-RAB23 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3212)
Fournisseur:
ProSci Inc.
Description:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α subunits and 2 rings are composed of 7 β subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3215)
Fournisseur:
ProSci Inc.
Description:
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. James et al. (1994) identified in hamster a farnesylated protein, called peroxisomal farnesylated protein or PxF, that localized to the outer surface of peroxisomes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3079)
Fournisseur:
ProSci Inc.
Description:
A carboxylic ester + H2O = an alcohol + a carboxylic anion. Homodimer. Cytoplasmic vesicles. There are two major electrophoretic isotypes. The sequence of the ESD*1 variant is shown. Similar to yeast HRE299.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-140)
Fournisseur:
ProSci Inc.
Description:
Anti-PAX6 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-293)
Fournisseur:
ProSci Inc.
Description:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-343)
Fournisseur:
ProSci Inc.
Description:
Lumican is a 40 kD secreted protein which belongs to the small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily. Human Lumican is synthesized as a 338 amino acid precursor then cut the 18 aa signal sequence. The mature Human Lumican contains 12 leucine-rich repeats (LRRs), 4 potential sites of N-linked glycosylation, and a C- terminal with two conserved cyst-eines. Lumican can be existed in extracellular matrix of human articular cartilage. Lumican participates in the maintenance of tissue homeostasis and regulates cellular functions in vivo, such as cell proliferation, adhesion, migration, and differentiation. The overexpression of lumican has been correlated to colorectal tumor, breast, neuroendocrine, and pancreatic cancers.
UOM:
1 * 50 µG
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