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ProSci Inc.
Numéro de catalogue:
(PRSI79-645)
Fournisseur:
ProSci Inc.
Description:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXPS-1014)
Fournisseur:
ProSci Inc.
Description:
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-alpha Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI79-637)
Fournisseur:
ProSci Inc.
Description:
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-702)
Fournisseur:
ProSci Inc.
Description:
cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-684)
Fournisseur:
ProSci Inc.
Description:
DMRT2 is a protein disclosed by NIH MGC program
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-689)
Fournisseur:
ProSci Inc.
Description:
This protein was disclosed by the RIKEN Mouse Gene Encyclopaedia Project, a systematic approach to determining the full coding potential of the mouse genome, involves collection and sequencing of full length complementary DNAs and physical mapping of the corresponding genes to the mouse genome.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-701)
Fournisseur:
ProSci Inc.
Description:
Homez and members of ZHX family of zinc finger homeodomain factors are delineated as a subset within the superfamily of homeobox-containing proteins.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-694)
Fournisseur:
ProSci Inc.
Description:
Dmrta1 is a DM domain containing transcription factors (DM = dsx and mab-3) and may be involved in sexual development
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-405)
Fournisseur:
ProSci Inc.
Description:
Anti-COPS3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-409)
Fournisseur:
ProSci Inc.
Description:
Anti-DCX Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-641)
Fournisseur:
ProSci Inc.
Description:
Endothelial cell-specific molecule–1 (ESM-1)—so-called endocan—is a novel endothelium derived soluble dermatan sulphate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL)-1 beta and tumour necrosis factor (TNF)- alpha, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1—Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1—Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumour progression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-653)
Fournisseur:
ProSci Inc.
Description:
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signalling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-652)
Fournisseur:
ProSci Inc.
Description:
CD64 (Fc gamma RI), one of the Fc receptors for IgG, is a membrane glycoprotein that mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. CD64 is also structurally distinct, containing an extracellular Ig-interactive region of three Ig-like domains in contrast to the two domains of the low affinity receptors Fc gamma RII and Fc gamma RIII. It is normally expressed on the surfaces of monocytes and macrophages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5749)
Fournisseur:
ProSci Inc.
Description:
SAE1 Antibody: Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (SUMO-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. This sumoylation is effected by the heterodimeric enzyme SAE1/SAE2 and the SUMO-1-conjugating enzyme Ubch9. The sumoylation pathway mediated by SAE1/SAE2 is distinct from other ubiquitin-like protein (Ubl) pathways.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-259)
Fournisseur:
ProSci Inc.
Description:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-827)
Fournisseur:
ProSci Inc.
Description:
Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins.Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins (Gray et al., 2001 [PubMed 11597136]).
UOM:
1 * 50 µG
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