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Numéro de catalogue:
(PRSI92-700)
Fournisseur:
ProSci Inc.
Description:
Tumour necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumour necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells. TNF RII binds to the membrane bound forms of TNF alpha and Lymphotoxin alpha/TNF beta ;soluble TNF is thought to signal predominately through TNF RI. Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-695)
Fournisseur:
ProSci Inc.
Description:
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumour cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumour cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumour associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-138)
Fournisseur:
ProSci Inc.
Description:
The ZA20D1 gene encodes an enzyme that cleaves ubiquitin from proteins. This gene has the ability to down-regulate NF-kappa B which plays a pivotal role in inflammatory processes through induction of adhesion molecules and chemokines.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-760)
Fournisseur:
ProSci Inc.
Description:
Lmx1a acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. It is required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-755)
Fournisseur:
ProSci Inc.
Description:
Spic represents a subgroup within the Ets protein family. It is a regulatory molecule during a specific phase of B lymphoid development
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-759)
Fournisseur:
ProSci Inc.
Description:
TAF7I belongs to the family of TATA box binding protein (Tbp)-associated factors. Promoter selectivity for all three classes of eukaryotic RNA polymerases is brought about by multimeric protein complexes containing TATA box binding protein (TBP) and specific TBP-associated factors (TAFs).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-142)
Fournisseur:
ProSci Inc.
Description:
KLHL25 is also known as ENC2. It is a BTB/POZ KELCH domain protein
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-146)
Fournisseur:
ProSci Inc.
Description:
KCNIP4 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-749)
Fournisseur:
ProSci Inc.
Description:
RelB is a member of the Rel/nuclear factor (NF)-kappa B family of transcription factors, defects in RelB affects antigen presenting cells and the formation of lymphoid organs. Targeted disruption of the Rel/NF-kappaB family members NF-kappaB2, encoding p100/p52, and RelB in mice results in anatomical defects of secondary lymphoid tissues.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-753)
Fournisseur:
ProSci Inc.
Description:
PPARdelta is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-757)
Fournisseur:
ProSci Inc.
Description:
Mybbp1a may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3949)
Fournisseur:
ProSci Inc.
Description:
PKR Antibody: The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3915)
Fournisseur:
ProSci Inc.
Description:
Avian Influenza Nonstructural Protein 1 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called "avian flu" or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2'-5'OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI30-689)
Fournisseur:
ProSci Inc.
Description:
The exact function of LOC344065 remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-651)
Fournisseur:
ProSci Inc.
Description:
The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2–Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilisation rates. Knockout females also display a reduced number of primary follicles.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI30-373)
Fournisseur:
ProSci Inc.
Description:
AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. There are a few putative pseudogenes for this gene, and one of them has been confirmed and mapped to chromosome 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM:
1 * 1 EA
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