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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Thymus-expressed chemokine (TECK), or CCL25, is a member of the CC family of chemokines that regulates the movement of lymphocytes in the thymus and in the small intestine. TECK induces chemoattraction by binding the chemokine receptor CCR9, which is expressed on immature pre-T cells and thymocytes (Youn <i>et al.</i>; Uehara <i>et al.</i>). In the thymus, TECK is produced by stromal cells, whereas in the small intestine TECK is primarily produced by epithelial cells (Vicari <i>et al.</i>; Bowman <i>et al.</i>; Kunkel <i>et al.</i>). CCR9 is a G protein-coupled receptor and is expressed on most thymocytes, but not on natural killer cells, monocytes, eosinophils, basophils, and neutrophils (Wu et al). In Jurkat cells, binding of TECK to CCL9 has been shown to increase levels of intracellular calcium (Cheng-Rong et al). TECK/CCR9 signaling has also been linked to many cancers, as these molecules have been shown to mediate anti-apoptotic processes by activating the PI3K/AKT signaling pathway, weakening the effect of cytotoxic T cells by regulating STAT signaling. Additionally, TECK induces metastasis by increasing the expression of MMP2 and MMP9 (Tu <i>et al.</i>).
Numéro de catalogue:
(STMC100-1334)
Fournisseur:
STEMCELL Technologies
Description:
Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn <i>et al.</i>). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui <i>et al.</i>, Schraufstatter <i>et al.</i>). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen <i>et al.</i>).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang <i>et al.</i>). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout <i>et al.</i>). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1338)
Fournisseur:
STEMCELL Technologies
Description:
A type 1 membrane glycoprotein belonging to the immunoglobulin superfamily, cluster of differentiation 200 (CD200) binds the CD200 receptor (CD200R) that is expressed on the surface of myeloid cells and T cells (Wright <i>et al.</i>), and has been shown to inhibit myeloid cell activity and macrophage cytokine production (Jenmalm <i>et al.</i>). Homologues of CD200 have been identified in viruses and can interact with CD200R to reduce macrophage pro-inflammatory cytokine production (Foster-Cuevas <i>et al.</i>). Studies have shown that the immunosuppressive effects of CD200 can promote acceptance of allogeneic tissue grafts in hosts (Gorczynski <i>et al.</i>), whereas dysregulation of CD200/CD200R can contribute to the development of autoimmune conditions, such as rheumatoid arthritis (Ren <i>et al.</i>). CD200 contains two immunoglobulin-like domains, a V-type domain and a smaller C2-type domain (Hatherley <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, cluster of differentiation 200 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein. Human recombinant CD200 at 2 μg/ml can bind human CD200R (His and hFc tag) with a linear range of 5 to 28 ng/ml, as determined by functional ELISA.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1325)
Fournisseur:
STEMCELL Technologies
Description:
Use omentin for the maintenance of insulin sensitivity and metabolism, decreasing levels of this adipokine have been associated with obesity, insulin resistance, and diabetes (Tan <i>et al.</i>). Studies have suggested that omentin may have protective effects against atherosclerosis, arterial calcification, and myocardial injury through AMP-activated protein kinase (AMPK) and Akt-dependent mechanisms (Xu <i>et al.</i>, Kataoka <i>et al.</i>). Through regulation of Sirt1-dependent p53 deacetylation, omentin can inhibit proliferation and induce apoptosis in hepatocellular carcinoma cells (Zhang and Zhou). Omentin is mainly produced by visceral adipose tissue, but is also expressed in the small intestine, colon, mesothelial cells, vascular cells, and plasma (Watanabe et al). Protein sequence analysis has shown that omentin comprises 313 amino acids, with a secretory signal sequence and fibrinogen-related domain (Yang <i>et al.</i>). For consistency and reproducibility across your applications, Omentin from STEMCELL comes lyophilised with ≥90% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤5,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1391)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with EBV (HLA Class I Control) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (HLA Class I Control) Peptide Pool is a lyophilised mixture of 26 peptides from Epstein-Barr virus (EBV), and consists of defined HLA class I-restricted T cell epitopes. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development. For consistency and reproducibility across your applications, CMV peptide pool from STEMCELL has a purity ≥95%.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1392)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HPV16 (L1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (L1) Peptide pool is a lyophilised mixture of 124 peptides from major capsid protein L1 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 505 on L1. L1 enters the nuclei of host cells via a Kap α2β1-mediated pathway (Nelson <i>et al.</i>). It cooperates with E2, another viral protein, to enhance viral DNA replication (Siddiqa <i>et al.</i>). L1 pentamers can assemble into virus-like particles (Chen <i>et al.</i> 2000; Chen <i>et al.</i> 2001). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1387)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with EBV (EBNA-3B) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (EBNA-3B) Peptide Pool is a lyophilised mixture of 234 peptides from Epstein-Barr nuclear antigen 3B (EBNA-3B) of Epstein-Barr virus (EBV; strain AG876) and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 946 on EBNA-3B. EBNA-3B is considered non-essential for B cell growth transformation (Chen <i>et al.</i>, 2005; Tomkinson and Kieff), but has been shown to regulate the expression of cellular genes in EBV-infected cells (Chen at al., 2006). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1614)
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, PerCP-Cy5.5-conjugated.
UOM:
1 * 1 EA
New Product
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Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human neutrophils.
Numéro de catalogue:
(STMC05445)
Fournisseur:
STEMCELL Technologies
Description:
Animal component-free medium for human mesenchymal stem cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0338)
Fournisseur:
STEMCELL Technologies
Description:
Apoptosis staining and detection kit - 100 tests.
UOM:
1 * 100 ST
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Numéro de catalogue:
(STMC100-1345)
Fournisseur:
STEMCELL Technologies
Description:
Rabbit monoclonal antibody against human Synaptophysin (MRX96).
UOM:
1 * 100 µl
New Product
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Numéro de catalogue:
(STMC100-1342)
Fournisseur:
STEMCELL Technologies
Description:
Rabbit polyclonal antibody against human MAP2 (MAP-2).
UOM:
1 * 200 µl
New Product
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Numéro de catalogue:
(STMC10974)
Fournisseur:
STEMCELL Technologies
Description:
Serum-free and animal component-free culture supplement for expansion of human B cells.
UOM:
1 * 2 mL
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Numéro de catalogue:
(STMC17847)
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic depletion of human TCRa/b+ cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC17892)
Fournisseur:
STEMCELL Technologies
Description:
Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.
UOM:
1 * 1 Kit
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