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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer <i>et al.</i>). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine et al; Ware and Matthay). FGF-10 also has a role in mobilisation and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong <i>et al.</i>; Ware and Matthay), as well as endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi <i>et al.</i>).
Numéro de catalogue:
(STMC100-0318)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.
UOM:
1 * 1 EA
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
SARS-CoV-2 Recombinant Spike Protein, aa319-541 is expressed in <i>Pichia pastoris</i> and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells allowing invasion through clathrin-mediated endocytosis. The spike protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit, and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. At the amino terminus of the polypeptide chain, SARS-CoV-2 Recombinant spike protein contains a polyhistidine tag and a SUMOstar site.
Fournisseur:
STEMCELL Technologies
Description:
Human Recombinant Angiotensin-Converting Enzyme 2 (ACE2) Protein, aa18-740, is expressed in HEK293 cells. ACE2 activity results in vasodilation by degrading vasoconstrictor angiotensin II to produce vasodilator angiotensin. Decreased expression of this enzyme is associated with cardiovascular disease and possibly also glomerular injury in diabetic nephropathy. ACE2 contains a peptidase domain at the N-terminus and a single transmembrane helix. ACE2 is also the primary human receptor for the surface spike glycoprotein of SARS-CoV-2 and SARS-CoV. This receptor is expressed in human lung and small intestine epithelia as well as the heart, kidney, and testes. The peptidase domain of ACE2 binds to the protein-binding domain of the S1 protein subunit of the spike protein; this binding results in a cleavage site becoming exposed. Cleavage, or ‘protein priming’, is done by TMPRSS2, a cellular serine protease, and by cathepsins. This cleavage activates the S2 subunit of the spike protein, allowing the fusion of the viral membrane to the host cell membrane. At the carboxy terminus, Human Recombinant ACE2 Protein contains a TEV site and a human IgG1 Fc tag.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG, antibody against mouse, CD152 (CTLA-4), PE-conjugated.
Numéro de catalogue:
(STMC100-0505)
Fournisseur:
STEMCELL Technologies
Description:
FRET-based peptide substrate for detection of protease activity of coronaviruses - 100 tests.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
A cellular protein for detection of apoptotic cells, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2a, antibody against human, rhesus, cynomolgus HLA-DR, FITC-conjugated.
Numéro de catalogue:
(STMC100-0939)
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 1 receptor antagonist (IL-1RA) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular signaling (Arend <i>et al.</i>). IL-1RA is a natural regulator of IL-1’s biological activity. It binds to the IL-1 receptors with similar affinity as IL-1, thereby inhibiting the proinflammatory activities of IL-1ɑ and IL-1ꞵ (Kinne <i>et al.</i>). In particular, mesenchymal stem cells have been shown to enhance tissue repair in an IL-1RA-dependent manner through the suppression of IL-1ꞵ production in dermal macrophages and enhanced expansion of immunosuppressive regulatory T cells in the skin (Harrell <i>et al.</i>). IL-1RA has also been shown to help in the treatment of rheumatoid arthritis (Cutolo), sepsis, asthma (Mao <i>et al.</i>), and inflammatory bowel diseases (Dosh <i>et al.</i>). This product is animal component-free.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0851)
Fournisseur:
STEMCELL Technologies
Description:
Fluorescent dyes used to label and track lysosomes in live cells - 500 tests.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human B cells.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, PE-conjugated.
Numéro de catalogue:
(STMC100-0287)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2a, antibody against human CD3, unconjugated.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of any cells with your own mouse IgG1 antibody.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human eosinophils.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2).
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