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Anticorps
Numéro de catalogue:
(BOSSBS-5791R-A750)
Fournisseur:
Bioss
Description:
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5795R-A488)
Fournisseur:
Bioss
Description:
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3541R-CY7)
Fournisseur:
Bioss
Description:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7600R-A555)
Fournisseur:
Bioss
Description:
Target of p53/TP53 with pro-apoptotic function.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3541R-CY5)
Fournisseur:
Bioss
Description:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11129R-CY7)
Fournisseur:
Bioss
Description:
May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7600R-FITC)
Fournisseur:
Bioss
Description:
Target of p53/TP53 with pro-apoptotic function.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11128R-A750)
Fournisseur:
Bioss
Description:
Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the Signalling between axons and myelinating glial cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4131R-CY5.5)
Fournisseur:
Bioss
Description:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8172R-A647)
Fournisseur:
Bioss
Description:
Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).Tissue specificity:Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4131R-A680)
Fournisseur:
Bioss
Description:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11618R-A647)
Fournisseur:
Bioss
Description:
RTP4
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11617R-HRP)
Fournisseur:
Bioss
Description:
The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R50 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(50-8034-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-mouse IgG (H+L), secondary antibody, conjugated to SureLight® R-Phycoerythrin, 1mg
UOM:
1 * 1 mg
Numéro de catalogue:
(30-8067-M002)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Rabbit IgG (H&L) - Affinity Pure, Biotin Conjugate
UOM:
1 * 2 mg
Numéro de catalogue:
(72-8098-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Guinea Pig IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, chicken, goat, hamster, horse, human
UOM:
1 * 1 mg
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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