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ACE+HILIC
Numéro de catalogue:
(PRSI92-277)
Fournisseur:
ProSci Inc.
Description:
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the Tax-responsive element (TRE) of HTLV-I. ATF1 mediates PKA-induced stimulation of CRE-reporter genes, represses the expression of FTH1 and other antioxidant detoxification genes, triggers cell proliferation and transformation. ATF1 is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and CDK3. Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.
UOM:
1 * 50 µG
Fournisseur:
Thermo Orion
Description:
Instrument facile à utiliser et économique pour une large gamme d'applications et d'analyses de pH avancées en laboratoire. Idéal pour les mesures de pH, de mV et de température simples et de routine.
Fournisseur:
EUTECH
Description:
Cet appareil de mesure portable est étanche à l'eau et conforme aux exigences de l'indice de protection IP 67.
Numéro de catalogue:
(PRSI25-363)
Fournisseur:
ProSci Inc.
Description:
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF3 represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
UOM:
1 * 50 µG
Fournisseur:
Thermo Orion
Description:
This benchtop meter is ideal for a wide range of applications and advanced pH and conductivity analysis in the lab. It offers two measuring channels allowing users to measure pH and conductivity simultaneously or view each channel separately.
Fournisseur:
Thermo Orion
Description:
This rugged, waterproof portable meter is designed for a wide range of pH, ion concentration, mV, ORP and temperature testing and field applications. It can be used in the most demanding locations thanks to its IP 67-rated housing. The meter offers one measuring channel.
Fournisseur:
Thermo Orion
Description:
These bench top meters record accurate and reliable pH, ion concentration, mV, ORP and temperature measurements. They are ideal for a wide range of applications and advanced pH or ion analysis in the lab.
Fournisseur:
Thermo Orion
Description:
This portable pH meter is designed a wide range of pH, mV, ORP and temperature testing and field applications. The meter is suitable for use in the most demanding locations thanks to its IP 67-rated housing.
Numéro de catalogue:
(PRSI79-710)
Fournisseur:
ProSci Inc.
Description:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM:
1 * 1 EA
Fournisseur:
Thermo Scientific
Description:
di-Sodium L(+)-tartrate dihydraté 99.0-101.0% ACS
Fournisseur:
Thermo Orion
Description:
These bench top meters with conductivity module meet most challenging applications for pH, ion concentration, mV, ORP and temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements.
Fournisseur:
Thermo Orion
Description:
This rugged, waterproof portable meter is designed for a wide range of pH, mV, ORP, conductivity, total dissolved solids (TDS), salinity, resistivity and temperature testing and field applications. It can be used in the most demanding locations thanks to its IP67-rated housing. The meter offers two measuring channels allowing users to measure pH and conductivity simultaneously or view each channel separately.
Numéro de catalogue:
(PRSI33-838)
Fournisseur:
ProSci Inc.
Description:
The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), 6-8, 11-13 and 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.
UOM:
1 * 1 EA
New Product
Fournisseur:
Thermo Orion
Description:
These bench top meters with two measuring channels are designed for accurate and reliable pH, ion concentration, mV, ORP and temperature measurements. Ideal for high throughput pH and ion analysis in the lab.
Fournisseur:
Thermo Orion
Description:
This rugged, waterproof portable meter is ideal for a wide range of applications and advanced pH analysis in the field. It measures pH, mV, relative mV or ORP with temperature and can be used in the most demanding locations thanks to its IP 67-rated housing.
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'
est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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