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Single-use+Pressure+Sensor
Numéro de catalogue:
(UPCHP-450)
Fournisseur:
UPCHURCH SCIENTIFIC
Description:
Conçue pour séparer et contrôler avec précision un écoulement à faible débit d'une source unique.
UOM:
1 * 1 ST
Numéro de catalogue:
(BOSSBS-6125R-A680)
Fournisseur:
Bioss
Description:
Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6124R-FITC)
Fournisseur:
Bioss
Description:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9491R-A488)
Fournisseur:
Bioss
Description:
The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6634R-A680)
Fournisseur:
Bioss
Description:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM:
1 * 100 µl
Numéro de catalogue:
(MMMA7100260645)
Fournisseur:
3M
Description:
For effective protection against a range of particulates, gases and vapours or combination hazards, use 3M™ Filters DT-Series. Suitable for use with certain 3M™ half and full-face tight-fitting respirators in negative-pressure mode as well as 3M™ Powered Air Respirator System PF-600E+ Series.
UOM:
1 * 1 ST
New Product
Fournisseur:
VACUUBRAND GMBH + CO
Description:
La jauge DCP 3000 est une jauge de vide exceptionnelle équipée d'un grand écran éclairé. Le tout nouveau capteur de vide VSP 3000 est fondé sur la conductivité thermique (Pirani) et propose une large plage de mesure, allant de la pression atmosphérique jusqu'à 10-3 mbar. Les pièces humides sont composées de plastiques (PBT, PUR) et de céramiques d'alumine résistants aux produits chimiques. Sa résistance chimique et sa solidité sont bien meilleures que celles des capteurs Pirani classiques, avec leur filament métallique en spirale plus fragile. La possibilité de connecter simultanément jusqu'à huit capteurs de vide donne davantage de flexibilité pour réaliser des mesures sur site. Le DCP 3000 communique avec les composants externes via le système de bus numérique VACUU BUS®. Il se caractérise par une configuration entièrement automatique, des connexions de prise unifiées et des longueurs de câble allant jusqu'à 30 m. De plus, le DCP 3000 offre des mesures de la pression relative (VSK 3000 comme référence) ainsi qu'une fonction d'enregistrement des données qui peut garder en mémoire jusqu'à 32000 valeurs de données.
Fournisseur:
Thermo Scientific
Description:
Silica gel 60 is used as carriers, processing aids, anti-caking and free-flow agents in animal feed. Defoamer applications such as paint, food, paper, textile and other industrial applications. Synthetic silicon dioxides are used as a rheology control agent in plastics. It is also used in dry column chromatography without applied pressure (gravity pulled).
Fournisseur:
ENTEGRIS INC
Description:
Available compliant to SEMI Standard F57-0312, the specification for polymer components used in ultrapure water and liquid chemical distribution systems. Higher performance with greater back (outlet) pressure capability. All wetted parts are molded PFA providing chemical resistance suitable for use in high purity, high corrosive chemical handling applications.
Fournisseur:
VWR Collection
Description:
Les VCP 80 et VCP 130 peuvent être utilisées comme pompes à vide et à pression et établissent une norme pour une utilisation efficace du vide. Utilisez ces pompes comme une application d'aspiration abordable où la résistance à la corrosion n'est pas nécessaire. Ces pompes peuvent être utilisées pour la filtration sous vide de solutions aqueuses ou de fumées aqueuses, y compris les tampons, mais ne sont pas recommandées pour le pompage de fumées acides, basiques ou organiques. Ces pompes à vide/pression VWR® Collection sont conçues pour un fonctionnement continu sans surveillance et disposent de deux comparateurs à cadran avec régulateurs manuels qui vous permettent de régler et de surveiller facilement le niveau de vide ou de pression requis.
Numéro de catalogue:
(PRSI90-361)
Fournisseur:
ProSci Inc.
Description:
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.
UOM:
1 * 50 µG
Fournisseur:
Avantor
Description:
On les utilise dans la chromatographie préparatoire à faible pression. Les spécifications des grilles garantissent qu'il n’y a pas de particules fines en excès dans le produit pouvant affecter es débits et les performances de séparation.
Numéro de catalogue:
(BOSSBS-6125R-A750)
Fournisseur:
Bioss
Description:
Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability.
UOM:
1 * 100 µl
Fournisseur:
Agilent
Description:
These inlet liners prevent adsorption and ensure accurate sample transfer onto the GC column through a robust deactivated surface. These liners are recommended for trace level analysis of active analytes. Liners with inert wool retain non-volatiles, prolonging column life and lowering frequency of MS source maintenance.
Fournisseur:
B. Braun
Description:
Pour toutes les pompes à seringue < pression de 4 bars.
Numéro de catalogue:
(BOSSBS-0356R-A680)
Fournisseur:
Bioss
Description:
Digoxin is a beta blocker drug originally derived from the foxglove plant, Digitalis lanata. Digoxin is used primarily to improve the pumping ability of the heart in congestive heart failure (CHF), and treat problems such as high blood pressure. It is also used to help normalize some dysrhythmias (abnormal types of heartbeat).
UOM:
1 * 100 µl
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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