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Single-use+Pressure+Sensor
Numéro de catalogue:
(ENZOADI905813100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling.
UOM:
1 * 1 EA
New Product
Fournisseur:
VWR Collection
Description:
Borosilicate 3.3 glass, with PP stopper. Single certified class A measuring flasks with imprinted serial number and individual work certificate.
Numéro de catalogue:
(BOSSBS-1380R-A647)
Fournisseur:
Bioss
Description:
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilisation and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
UOM:
1 * 100 µl
Fournisseur:
Spectrum Laboratories
Description:
Manomètre, Pressure Transducer, 1×1" TC, polysulfone, sterile, −10 - +75 psi
Fournisseur:
WARTEWIG
Description:
Gas safety adapter with integrated pressure regulator for EXPRESS 444
Fournisseur:
Restek
Description:
Vacuum/pressure gauge (−30" Hg/30 psi)
Numéro de catalogue:
(390-1660)
Fournisseur:
VWR Collection
Description:
Support frame on castors for single chamber, height 800 mm , Pour: ILCO 180 Premium
UOM:
1 * 1 ST
Fournisseur:
UPCHURCH SCIENTIFIC
Description:
Low pressure inline filters offer excellent protection for any low pressure application.
Numéro de catalogue:
(HICHHI-1125)
Fournisseur:
Avantor
Description:
Natural and M6 single ferrule nuts.
UOM:
1 * 10 ST
Fournisseur:
Agilent
Description:
Back pressure regulator, 100 psi for G1315B/DAD/MWD
Numéro de catalogue:
(HUBE9580)
Fournisseur:
HUBER
Description:
PS level controller, Pour: External open baths with pressure and suction pump and minichiller®
UOM:
1 * 1 ST
Numéro de catalogue:
(SUPL40121-100ML)
Fournisseur:
Merck
Description:
Single component solution suitable as ion chromatography standard.
UOM:
1 * 100 mL
Numéro de catalogue:
(HEWLG4301-60100)
Fournisseur:
Agilent
Description:
Flow cell, high pressure, flow path 10 mm, for supercritical fluid chromatography
UOM:
1 * 1 ST
Fournisseur:
Agilent
Description:
Accessoire pour spectrophotomètre UV/Vis, Cassette, variable pressure, Pour: 8453
Fournisseur:
Restek
Description:
Vacuum/pressure station allows switching from pressure to vacuum in a matter of seconds. It is quiet and has a oil-free unit which will not contaminate the extraction system or samples. Provides 20" Hg (68 kPa) vacuum or 18 psi (124 kPa) pressure.
Fournisseur:
VWR Collection
Description:
Vacuum aspiration system accessory, VWR®, Single needle Ø 1,5 mm, 40 mm for 4 and 2 L
Appel de prix
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 est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'
est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
Ces articles ne peuvent être ajoutés au Panier. Veuillez contacter votre service client ou envoyer un e-mail à vwr.be@vwr.com
Une documentation supplémentaire peut être nécessaire pour l'achat de cet article. Un représentant de VWR vous contactera si nécessaire.
Ce produit a été bloqué par votre organisation. Contacter votre service d'achat pour plus d'informations.
Le produit original n'est plus disponible. Le remplacement représenté est disponible
Les produits marqués de ce symbole ne seront bientôt plus disponibles - vente jusqu'à épuisement de stock. Des alternatives peuvent être disponibles en recherchant le code article VWR indiqué ci-dessus. Si vous avez besoin d'une assistance supplémentaire, veuillez contacter notre Service Clientèle au 016 385 011.
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