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Single-use+Pressure+Sensor
Numéro de catalogue:
(PRSI92-309)
Fournisseur:
ProSci Inc.
Description:
S100A6, also known as Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6 and CACY, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are a family of low molecular weight protein found in vertebrates and localised in the cytoplasm and/or nucleus of a wide range of cells.S100 proteins are involved in a number of fundamental biological processes such as protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, the inflammatory response,cell cycle progression and differentiation, stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. S100A6 may function as calcium sensor and modulator, contributing to cellular calcium signaling.It may function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganisation of the actin cytoskeleton and in cell motility.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIPM-4911)
Fournisseur:
ProSci Inc.
Description:
ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
UOM:
1 * 1 EA
Fournisseur:
Texwipe
Description:
Ces lingettes épaisses, pli unique, en polyester à rebord soudé offrent la même capacité d'absorption qu'une lingette deux plis. Elles sont adaptées à tous les usages ainsi que pour l'application de grands volumes de solutions de nettoyage et désinfection.
Fournisseur:
GUENZBURGER STEIGTECHNIK
Description:
Ascendable on one side, grooved steps with a depth of 80 mm with durable 'step to side' rail connection, non slip nivello® ladder feet. High standing safety ensured by conical construction.
Fournisseur:
Thermo Fisher Scientific
Description:
PS. Les modules Nunc-Immuno ™ LockWell™ facilitent les études diagnostiques, du dépistage à grande échelle aux tests individuels en puits. Disponibles avec des surfaces MaxiSorp™, PolySorp™, MediSorp™ et MultiSorp™. Homogénéité de liaison certifiée pour tous les modules MaxiSorp™. Les modules à cadre (dimensions extérieures : 128×86 mm) s'adaptent à tous les équipements standard.
Numéro de catalogue:
(ORIO9163SC)
Fournisseur:
Thermo Orion
Description:
This combination pH electrode with spear tip is ideal for piercing soft samples, such as cheese, meat, and fruit samples.
UOM:
1 * 1 ST
Numéro de catalogue:
(SELE3000389)
Fournisseur:
SELECTA
Description:
This immersion thermostat with electronic temperature control is fitted with a stirring circulating pump.
UOM:
1 * 1 Pce
Fournisseur:
Mettler - Toledo
Description:
Instruments à deux ou trois canaux, modulairement extensibles à tout moment, avec des paramètres de mesure supplémentaires.
Numéro de catalogue:
(662-1534)
Fournisseur:
Thermo Orion
Description:
Chemical resistant glass body combination electrode for clog-free measurements of soil, sludge, colloids, and viscous material.
UOM:
1 * 1 ST
Numéro de catalogue:
(STMC100-0930)
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 34 (IL-34) is well known for its ability to induce the formation of colony-forming unit macrophages in human bone marrow cell cultures (Foucher <i>et al.</i>; Wei <i>et al.</i>). This dimeric glycoprotein is a member of the short-chain helical hematopoietic cytokine family (Baghdadi <i>et al.</i>; Foucher <i>et al.</i>), and exists in two isoforms that differ by a single glutamine (Chen <i>et al.</i>; Foucher et al; Wei <i>et al.</i>). IL-34 interacts with M-CSF to trigger tyrosine phosphorylation of the receptor and ERK1/2 pathways. (Wang <i>et al.</i>; Wei <i>et al.</i>). It is expressed in many tissues (heart, brain, lung, liver, kidney, thymus, testes, ovary, small intestine, prostate, and colon), with the highest expression in the spleen. In combination with RANKL, IL-34 induces osteoclast differentiation (Chen <i>et al.</i>; Foucher <i>et al.</i>). IL-34 expression is decreased in Alzheimer’s disease and atopic dermatitis, while high levels of IL-34 are found in many types of cancer correlated with poor prognosis, chronic heart failure or coronary artery disease, inflammatory bowel disease, influenza A infection, during acute liver transplant rejection or in non-alcoholic fatty liver disease, and with rheumatoid arthritis (Baghdadi <i>et al.</i>). It is therefore a possible pharmacological target for treating bone or inflammatory diseases (Chen <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain, and the protein was purified as a homodimer consisting of 39 kDa monomers (Lin <i>et al.</i>).
UOM:
1 * 1 EA
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
KIMBERLY CLARK
Description:
Gants stériles spécifiques aux mains avec manchette à bord roulé pour applications en salle blanche. Lorsqu'ils sont enfilés deux fois, ces gants offrent la sensation et la dextérité équivalentes à un seul gant en latex sans risque de réactions
Numéro de catalogue:
(665-0291)
Fournisseur:
KNICK
Description:
Cet appareil de mesure intuitif et portable convient aux mesures quotidiennes de l’oxygène. Sa polyvalence et sa robustesse en font le produit idéal pour les applications de laboratoire et de développement de procédés. Étanchéité IP 66/IP 67.
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI29-213)
Fournisseur:
ProSci Inc.
Description:
SMN1 localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants are produced by this gene.
UOM:
1 * 50 µG
Fournisseur:
Thermo Scientific
Description:
Les incubateurs à CO₂ HERAcell® i fournissent des conditions de croissance stables et précises qui offrent une excellente protection contre la contamination des cultures précieuses de cellules et de tissus. Les temps de récupération de CO₂ et de température extrêmement courts améliorent la croissance cellulaire – Disponibles en deux tailles pratiques et deux conceptions de chambre intérieure ; acier inoxydable non corrosif et cuivre massif 100% antimicrobien (pour prévenir la prolifération naturelle des bactéries et des champignons). Les modèles standard sont fournis avec des capteurs de conductivité thermique (TC) de haute qualité.
Numéro de catalogue:
(BSBTPB9091)
Fournisseur:
BosterBio
Description:
Polyclonal antibody for APP detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. APP information: Molecular Weight: 86943 MW; Subcellular Localization: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions; Tissue Specificity: Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T- lymphocytes. Appican is expressed in astrocytes.
UOM:
1 * 1 EA
Numéro de catalogue:
(662-1502)
Fournisseur:
Thermo Orion
Description:
Its spear tip makes this electrode ideal for pH measurement in semi-solid food material such as cheese, meat, fruit, bread and other similar samples. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.
UOM:
1 * 1 ST
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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