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Single-use+Temperature+Sensor
Numéro de catalogue:
(BOSSBS-1906R-A350)
Fournisseur:
Bioss
Description:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1136R-HRP)
Fournisseur:
Bioss
Description:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM]
UOM:
1 * 100 µl
Numéro de catalogue:
(620-2300)
Fournisseur:
VWR Collection
Description:
Affichage de l’heure, de la température et de l’humidité depuis n’importe où
UOM:
1 * 1 ST
Numéro de catalogue:
(EDVO631)
Fournisseur:
EDVOTEK
Description:
Practical, durable safety spectacles offering good protection and comfort.
UOM:
1 * 1 ST
Numéro de catalogue:
(BOSSBS-11277R-A350)
Fournisseur:
Bioss
Description:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3027R-FITC)
Fournisseur:
Bioss
Description:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1116R-A350)
Fournisseur:
Bioss
Description:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
UOM:
1 * 100 µl
Numéro de catalogue:
(HACH2217515)
Fournisseur:
Hach
Description:
Lauryl tryptose broth tubes with MUG microbiological media, single strength.
UOM:
1 * 15 ST
Fournisseur:
Avantor Fluid Handling
Description:
Provide easy, secure sterile connections even in nonsterile environments.
Fournisseur:
MAXX
Description:
Maxx single-board control, Pour: Spare part
Fournisseur:
VWR Chemicals
Description:
Solutions tampons, étalons secondaires , Valeur pH: 12,45, ±0,05, Température de réference: 25 °C, VWR®, Bouteille en plastique
Numéro de catalogue:
(613-1682)
Fournisseur:
Brand
Description:
Single stand for one Transferpette® or Transferpette® S mechanical pipette (multichannel).
UOM:
1 * 1 ST
Fournisseur:
Thermo Scientific
Description:
Usable temperature range: 25 to 250 °C (open system) and 25 to 315 °C (closed system)
Numéro de catalogue:
(BOSSBS-1388R-CY5)
Fournisseur:
Bioss
Description:
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth.
UOM:
1 * 100 µl
Fournisseur:
VWR Collection
Description:
Les enregistreurs de température et d’humidité TraceableGO Bluetooth complètent les inconnues entre les destinations. Le périphérique Bluetooth est le partenaire de transit idéal pour la surveillance des matériaux entre les destinations. Transportez en toute sécurité les réactifs, les échantillons cliniques, les vaccins, les produits pharmaceutiques et les produits alimentaires vers n’importe quel lieu.
Numéro de catalogue:
(620-0892)
Fournisseur:
VWR Collection
Description:
Ce thermomètre a été conçu pour indiquer les plages de températures critiques. La plage 4 à 6 °C est identifiée par des flèches.
UOM:
1 * 1 ST
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 est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'
est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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Une documentation supplémentaire peut être nécessaire pour l'achat de cet article. Un représentant de VWR vous contactera si nécessaire.
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Les produits marqués de ce symbole ne seront bientôt plus disponibles - vente jusqu'à épuisement de stock. Des alternatives peuvent être disponibles en recherchant le code article VWR indiqué ci-dessus. Si vous avez besoin d'une assistance supplémentaire, veuillez contacter notre Service Clientèle au 016 385 011.
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