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Single-use+Temperature+Sensor


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Numéro de catalogue: (PRSI92-690)

Fournisseur:  ProSci Inc.
Description:   Human serum albumin (HSA), the most abundant protein in human blood plasma, is essential for maintaining osmotic pressure. It is produced in the liver, consists of a single polypeptide chain, with 585 amino acids with 17 tyrosil residues and one tryptophan located in position 214. HSA is organised in three domains, I, II and III, each consisting of two subdomains, A and B. In the physiological states, HSA occurs in two forms – the non-modified HSA with a free thiol group of Cys-34, and the modified (oxidised) form (oHSA), also called human mercaptoalbumin (HMA) and human nonmercaptoalbumin (HNA), respectively. HMA and HNA are in equilibrium, depending on the redox state of Cys-34, and their ratio also varies depending on age and the diseased state. HSA functions primarily as a carrier protein for drugs, steroids, fatty acids, and thyroid hormones, and plays a role in stabilising extracellular fluid volume.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI55-079)

Fournisseur:  ProSci Inc.
Description:   This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon.
UOM:  1 * 400 µl
New Product
Numéro de catalogue: (AATB16301)

Fournisseur:  AAT BIOQUEST INC
Description:   DAX-J2™ Red is a new nitric oxide (NO) sensor recently developed by AAT Bioquest.
UOM:  1 * 1 mg
New Product
Fournisseur:  Thermo Fisher Scientific
Description:   Refroidisseurs pour paillasse –20 °C.
PC, bleu.
Section inférieure remplie d'un gel non toxique, avec poignée.
471-0000/471-0001 : permet de maintenir une température inférieure à –15 °C pendant une durée pouvant aller jusqu'à 2 heures.
Seize inserts inclus pour la conversion d'orifices de 1,5 ml afin d'accepter des tubes de 0,5 ou 0,2 ml.
Environmentally Preferable

Fournisseur:  WTW
Description:   Electrolyte for amperometric oxygen sensors, 1 bottle with 50 ml
UOM:  1 * 50 mL
Numéro de catalogue: (PRSI91-431)

Fournisseur:  ProSci Inc.
Description:   Interferon alpha/ beta Receptor 2 (IFN- alpha/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN- alpha/ beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN- alpha/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN- alpha/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN- alpha/ beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI91-946)

Fournisseur:  ProSci Inc.
Description:   Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA), and ankylosing spondylitis and the resulting joint pathology. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally as monomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to either cell surface TNFR.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI90-417)

Fournisseur:  ProSci Inc.
Description:   CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulphide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
UOM:  1 * 500 µG
Numéro de catalogue: (733-1617)

Fournisseur:  LONZA
Description:   Le système FlashGel™ pour ARN est optimisé pour les besoins uniques de l'ARN et pour l'analyse rapide de l'intégrité des échantillons. Un ARN intact et de grande qualité est essentiel pour des résultats reproductibles en matière d'expression génétique, d'analyse Northern, de construction de bibliothèques d'ADN complémentaire et de marquage de l'ADN complémentaire pour les microarrays. La plupart des protocoles recommande de contrôler l'ARN avant l'analyse en aval.
UOM:  1 * 9 ST
Numéro de catalogue: (PRSI29-277)

Fournisseur:  ProSci Inc.
Description:   AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI91-294)

Fournisseur:  ProSci Inc.
Description:   SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI91-287)

Fournisseur:  ProSci Inc.
Description:   VCAM-1 is a single-pass type I membrane protein, contains 7 Ig-like C2-type domains. It is an endothelial ligand for very late antigen-4 (VLA-4) and alpha4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
UOM:  1 * 50 µG
Fournisseur:  WTW ONLINE
Description:   Sonde à oxygène dissous, Ecoline, TriOxmatic® 690-7, 0 - 60 mg/l ; 0 - 600%, 196 mm, 7 m de câble, avec fiche étanche (IP 65)
Fournisseur:  UPCHURCH SCIENTIFIC
Description:   Ces clapets antiretour intégrés et biocompatibles en PEEK et en perfluoroélastomère sont conçus pour des applications nécessitant un faible volume d'écoulement, comme l'administration à un dispositif de type laboratoire sur puce, l'analyse de cellules isolées et la dérivatisation post-colonne micro- ou nano-LC.
Numéro de catalogue: (HACH2315001)

Fournisseur:  Hach
Description:   Le kit de test Pool Master combine plusieurs test en un seul kit de test. Ce kit de test comprend des tests pour l'alcalinité (20 - 400 mg/l), le chlore libre et total (0 - 3,4 mg/l), la dureté (20 - 400 mg/l) et le pH (6,6 - 8,4 mg/l) et des tests spécialisés pour l'alcalinité totale, la dureté du calcaire et l'acide cyanurique.
UOM:  1 * 1 KIT
Fournisseur:  FRISTADS KANSAS GROUP
Description:   T-shirts 100% coton, jersey tubulaire simple.
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