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Single-use+Temperature+Sensor


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Numéro de catalogue: (PRSI91-601)

Fournisseur:  ProSci Inc.
Description:   Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, it may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
UOM:  1 * 50 µG
Numéro de catalogue: (INTG158403)

Fournisseur:  Integra
Description:   Vacuum aspiration system accessory, Câble de capteur de niveau
UOM:  1 * 1 ST
Numéro de catalogue: (ELET32587-00)

Fournisseur:  Cole-Parmer
Description:   Get accurate temperature control of heating equipment in your lab.
UOM:  1 * 1 ST
Numéro de catalogue: (PRSI90-412)

Fournisseur:  ProSci Inc.
Description:   CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
UOM:  1 * 500 µG
Fournisseur:  Lovibond
Description:   Électrolyte de rechange pour capteur d'oxygène, Pour: Multi-parameter meters SensoDirect 150
Numéro de catalogue: (PRSI6043)

Fournisseur:  ProSci Inc.
Description:   EFCAB4A Antibody: EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
UOM:  1 * 1 EA
Fournisseur:  Liebherr
Description:   La série Performance sans lumière et la série Perfection avec l'éclairage frontal LED assurent une luminosité optimale des tiroirs même dans les environnements sombres, pour une vue d'ensemble parfaite, la substance souhaitée est immédiatement à portée de main, la porte peut être refermée rapidement et la température intérieure reste stable. Pour une faible consommation et des coûts énergétiques réduits.
Numéro de catalogue: (PRSI50-193)

Fournisseur:  ProSci Inc.
Description:   Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).
UOM:  1 * 100 µl
Numéro de catalogue: (PRSI4041)

Fournisseur:  ProSci Inc.
Description:   ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
UOM:  1 * 1 EA
Fournisseur:  SIOEN PERSONAL PROTECTIVE CLOT
Description:   Chemise fluide 60% Protex®, 40% Viloft® (jersey simple). Tissu ignifuge possédant de bonnes propriétés anti-humidité et un traitement antibactérien.
Numéro de catalogue: (PRSI55-210)

Fournisseur:  ProSci Inc.
Description:   Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
UOM:  1 * 400 µl
New Product
Numéro de catalogue: (732-4301)

Fournisseur:  UVP ULTRA VIOLET PRODUCTS
Description:   Le four Hybrilinker associe un four à hybridation HB-1000 avec un CX-2000 Crosslinker, fonctionnant tous deux indépendamment. L'élément Crosslinker de l'appareil émet des UV à 254 nm pour permettre la liaison de l'ADN à une membrane en quelques secondes. La dose d'UV peut être saisie sous forme d'une durée ou d'une valeur en microjoules par cm² pour une exposition précise.
UOM:  1 * 1 ST

Fournisseur:  2MAG
Description:   The aluminium alloy block heater is PTFE coated for chemical resistance and easy cleaning. The combined stirring block heater has 8 stirring positions, 8 holes ( Ø 87,2 mm, depth 78 mm) which are suitable for 250 ml Erlenmeyer flasks.
UOM:  1 * 1 ST
Fournisseur:  BIOSEPAR
Description:   Le système ECO ParasiTrap® FixSepar® contient un tube I de traitement et de transport rempli (avec Medium A ECO) et un tube II de traitement avec système de filtre en acier inoxydable intégré. Accessoires: solution de séparation medium B, solution de coloration medium C, pipettes Pasteur à usage unique, cuillères et coton-tiges. Bouchons à vis supplémentaires pour tube II de traitement.
UOM:  1 * 50 Essai
Numéro de catalogue: (BSBTRP1036)

Fournisseur:  BosterBio
Description:   Polyclonal antibody for TIE2/TEK detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. TIE2/TEK information: Molecular Weight: 125830 MW; Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted; Tissue Specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
UOM:  1 * 1 EA
Numéro de catalogue: (BSBTPB9094)

Fournisseur:  BosterBio
Description:   Polyclonal antibody for CD31/PECAM1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: Flow Cytometry. Reactive species: Human. CD31/PECAM1 information: Molecular Weight: 82536 MW; Subcellular Localization: Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells; Tissue Specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
UOM:  1 * 1 EA
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