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Single-use+Temperature+Sensor
Numéro de catalogue:
(708-0044)
Fournisseur:
WTW ONLINE
Description:
Électrode, conductivité, Ecoline
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI55-210)
Fournisseur:
ProSci Inc.
Description:
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(1.04148.0001)
Fournisseur:
Merck
Description:
Rapides, ces tests facilitent le screening des micro-organismes pathogènes. Tests complets pour la détection des germes pathogènes et des toxines. Les résultats sont fiables et disponibles en seulement 20 minutes après pré-enrichissement. Les milieux d'enrichissement spécifiques aident à garantir la précision et la fiabilité des résultats des tests. Le format One-Step évite les erreurs durant la manipulation.
UOM:
1 * 25 Tests
Numéro de catalogue:
(GRSG600407)
Fournisseur:
Greisinger
Description:
This handheld meter with integrated absolute pressure sensor is suitable for measurements in air and non corrosive and non ionizing gases and liquids.
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI28-817)
Fournisseur:
ProSci Inc.
Description:
RCV1 is a member of the recoverin family of neuronal calcium sensors. RCV1 contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy.The protein encoded by this gene contains four calcium-binding EF-hand domains and belongs to the recoverin family of neuronal calcium sensors. Recoverin may prolong the termination of the phototransduction cascade by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy; an autoimmune disease of the retina caused by a tumor in another tissue.
UOM:
1 * 50 µG
Fournisseur:
RPB SAFETY LLC
Description:
The RPB GX4 gas monitor continually monitors the quality of supplied breathing air. As soon as the air is no longer of EN breathing air standard, the unit will alarm to warn the respirator wearer that air entering the respirator is no longer safe to breath.
Numéro de catalogue:
(453-0145)
Fournisseur:
VELP SCIENTIFIC
Description:
Plaques chauffantes avec plaques à revêtement en alliage d'aluminium qui offrent une répartition uniforme de la chaleur. Modèles avec une ou deux plaques au choix.
UOM:
1 * 1 ST
Numéro de catalogue:
(VELPF20500590)
Fournisseur:
VELP SCIENTIFIC
Description:
Robust multiple-position hotplate stirrer with four independent positions designed to guarantee safety, powerful stirring, and excellent heating for basic applications. Unit has epoxy painted aluminum housing.
UOM:
1 * 1 ST
New Product
Fournisseur:
Quantabio
Description:
FastMixes contient des tampons et des stabilisants optimisés pour une efficacité, une reproductibilité et une sensibilité maximales de PCR, avec TaqMan® et compositions chimiques de sonde MGB TaqMan®. Un des composants clés de PerfeCTa® qPCR FastMixes est l'ADN polymérase AccuFast™ <i>Taq</i> qui permet une activation instantanée et une cinétique rapide de polymérisation. Après activation thermique (20 secondes à 95 °C), les anticorps se dénaturent de manière irréversible et libèrent l'ADN polymérase <i>Taq</i> entièrement active et non modifiée. Cela assure une extension spécifique et efficace de l'amorce avec la commodité de l'ensemble de réactions à température ambiante. FastMixes offre une efficacité, une sensibilité et une spécificité optimales de PCR ainsi qu'un fort signal fluorescent avec des conditions de cycle rapides ou conventionnelles.
Fournisseur:
KNICK
Description:
Électrode, pH, SE 104 N, pH: 2...13, −5...+80 °C, Plastique, Membrane: Trou, Électrolyte: Polymer, Ø×L: 12×99 mm, DIN, Pour: Substances semi-solides
Numéro de catalogue:
(WINKWRT00011-XX010)
Fournisseur:
WINKLER GMBH
Description:
Plug-in power selector made from polystyrene with safety socket with integrated fuse.
UOM:
Numéro de catalogue:
(PRSI33-473)
Fournisseur:
ProSci Inc.
Description:
This antibody neutralises human TNFa mediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of hTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-763)
Fournisseur:
ProSci Inc.
Description:
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI5057)
Fournisseur:
ProSci Inc.
Description:
FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
UOM:
1 * 1 EA
Numéro de catalogue:
(REST24899)
Fournisseur:
Restek
Description:
Sealing Rings, O-rings, max. temperature 250 °C
UOM:
1 * 10 ST
Numéro de catalogue:
(PRSI33-216)
Fournisseur:
ProSci Inc.
Description:
This antibody is specific for a 17-26 kDa protein, which is identified as the cytokine TNF alpha (Tumor Necrosis Factor alpha). It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. It is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. It exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
UOM:
1 * 1 EA
New Product
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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