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Numéro de catalogue: (PRSI50-256)

Fournisseur:  ProSci Inc.
Description:   Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
UOM:  1 * 100 µl
Fournisseur:  Cytiva
Description:   Ni Sepharose™ excel est un milieu IMAC pré-chargé avec des ions nickel très fortement liés à un ligand chélatant. Les échantillons qui provoquent habituellement une réextraction des ions métalliques peuvent donc être chargés sur le milieu. Ni Sepharose™ excel est principalement conçu pour la capture et la purification des protéines marquées à l'histidine sécrétées dans les surnageants de cultures cellulaires des cellules eucaryotes telles que les cellules d'insectes ou les cellules CHO.
Fournisseur:  MP Biomedicals
Description:   Storage: -20 °C.
Adenosine 5'-triphosphate (ATP) and its phosphate bonds are the basic components of energy exchange in many biological systems.
Adenosine 5'-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems.
Numéro de catalogue: (PRSI5365)

Fournisseur:  ProSci Inc.
Description:   JMJD1A Antibody: The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI6121)

Fournisseur:  ProSci Inc.
Description:   ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
UOM:  1 * 1 EA
Numéro de catalogue: (786-411)

Fournisseur:  G-Biosciences
Description:   Insect PE LB™ has been developed for extraction of total biologically active, soluble proteins from adherent or suspension cultured insect cells, including Sf9 and Sf21. Insect PE LB™ utilises a mild non-ionic detergent and a proprietary combination of various salts and agents to enhance extraction and stability of proteins. The Insect PE LB™ is fully compatible with downstream processes, such as electrophoresis and chromatography. Depending on the required downstream application, additional agents such as reducing agents and protease inhibitors may be added into Insect PE LB™.
UOM:  1 * 250 mL
Numéro de catalogue: (PRSI4557)

Fournisseur:  ProSci Inc.
Description:   Ambra1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
UOM:  1 * 1 EA

Fournisseur:  Thermo Fisher Scientific
Description:   For fast, accurate titer analysis of monoclonal antibodies (MAbs) in harvest cell cultures. This column provides high throughput and accurate analyses through a combination of low backpressure and high efficiency. Its unique format makes automation of loading, binding, elution and collection using biocompatible systems quick and easy. A non-porous, polymeric resin with a hydrophobic divinylbenzene core and a hydrophilic surface optimised for affinity separation makes this column rugged and reproducible.
UOM:  1 * 1 ST

Fournisseur:  Dino-Lite / IDCP B.V.
Description:   These stable vertical desktop stands are designed to be used with Dino-Lite digital microscopes. Available as a standard and an ESD-safe model.
UOM:  1 * 1 ST
Numéro de catalogue: (SPCMSO193-500GM)

Fournisseur:  Spectrum Chemical
Description:   Sodium Pyruvate, Reagent is most often added to the cell culture media as an extra source of energy. Sodium pyruvate also has a protective action against hydrogen peroxide. The Reagent grade denotes that this chemical is the highest quality commercially available and that the American Chemical Society has not officially set any specifications for this material. Spectrum Chemical manufactured Reagent grade products meet the toughest regulatory standards for quality and purity.
UOM:  1 * 500 g
Fournisseur:  iST Scientific Ltd
Description:   Film perméable aux gaz, transparent et perforé pour les plaques en PP, PE, PS et COC. Idéal pour l'incubation à court terme, l'agriculture et le stockage de semences, le stockage d'insectes, les cultures cellulaires.
Numéro de catalogue: (PRSI50-254)

Fournisseur:  ProSci Inc.
Description:   Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease.
UOM:  1 * 100 µl

Fournisseur:  Merck
Description:   Ces unités de filtration par centrifugation conviennent à un grand nombre d'utilisations: concentration d'échantillons biologiques contenant des antigènes, des anticorps, des enzymes, des acides nucléiques ou des micro-organismes; purification de composants macromoléculaires présents dans des extraits de culture tissulaire ou lysats cellulaires, et élimination de protéines avant la HPLC; concentration de diluats de protéines ou protéines pre-purifiées provenant d'éluants de colonnes de séparation; dessalage, échange de tampon et dialyse de protéines; exclusion de taille et fractionnement des protéines.
UOM:  1 * 24 ST
Numéro de catalogue: (PRSI50-253)

Fournisseur:  ProSci Inc.
Description:   Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease.
UOM:  1 * 100 µl
Numéro de catalogue: (PRSI50-257)

Fournisseur:  ProSci Inc.
Description:   Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-M is the neurofilament middle or medium molecular weight polypeptide and runs on SDS-PAGE gels at 145-160 kDa, with some variability across species boundaries. Antibodies to NF-M are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-M antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease.
UOM:  1 * 100 µl
Fournisseur:  STEMCELL Technologies
Description:   Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda <i>et al.</i>). GM-CSF was first purified from the culture of mouse lung tissue after lipopolysaccharide treatment. GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>).
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