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cell+culture+plates
Fournisseur:
Mettler - Toledo
Description:
This conductivity measuring cell utilises the four- pole potentiometric method for measuring conductivity, which incorporates a series of four graphite poles embedded in the probe shaft. This design completely eliminates the polarisation, which frequently occurs with the two-plate amperometric method during measuring high conductivity solution.
Fournisseur:
Thermo Scientific
Description:
La série VIOS Heracell™ a été conçue pour les cultures sensibles telles que les cellules souches et primaires dans la recherche de pointe, l'industrie pharmaceutique et les applications cliniques. Les unités sont disponibles avec un intérieur en acier inoxydable poli électrolytiquement ou en 100% cuivre, disposent d'étagères réglables et perforées, de coins faciles à nettoyer avec port d'accès pratique et porte extérieure réversible pour plus de flexibilité.
Numéro de catalogue:
(PRSI90-455)
Fournisseur:
ProSci Inc.
Description:
Epidermal growth factor (EGF) is a growth factor and the founding member of the EGF family. All EGF family members are synthesised as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis. EGF is present in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid. Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members. These receptors undergo a complex pattern of ligand induced homo or heterodimerisation to transduce EGF family signals. EGF binds to the receptor EGFR stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity initiates a signal transduction cascade that results in a variety of biochemical changes within the cell, including a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR, which lead to DNA synthesis, cell growth, proliferation and differentiation. Other biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4), also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterised by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-912)
Fournisseur:
ProSci Inc.
Description:
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6221)
Fournisseur:
ProSci Inc.
Description:
LRRFIP2 Antibody: The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of beta-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kappa B during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.
UOM:
1 * 1 EA
Numéro de catalogue:
(734-1273)
Fournisseur:
Corning
Description:
La laminine, l'un des principaux composants des membranes basales, est à l'origine de différentes activités biologiques, elle favorise notamment l'adhésion, la migration, la croissance et la différenciation des cellules, y compris la formation de neurites. Elle peut être utilisée comme fin revêtement des surfaces des cultures tissulaires ou comme additif soluble à un milieu de culture. Le complexe laminine/entactine haute concentration est une formulation spéciale développée pour la culture tridimensionnelle (3D).
UOM:
1 * 10,5 mg
Fournisseur:
Heidolph Instruments GmbH & Co.KG
Description:
Pour un mélange vigoureux des microplaques de titrage. L'amplitude de vibration de 1,5 mm garantit l'absence d'éclaboussures, même avec des récipients pleins ; celle de 3 mm assure des résultats de mélange optimaux, même en quantités infimes. Les agitateurs conçus pour une utilisation continue sont équipés d'une protection anti-surchauffe et d'une plate-forme isolée pour une accumulation de chaleur quasi nulle.
Numéro de catalogue:
(PRSI33-216)
Fournisseur:
ProSci Inc.
Description:
This antibody is specific for a 17-26 kDa protein, which is identified as the cytokine TNF alpha (Tumor Necrosis Factor alpha). It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. It is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. It exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
UOM:
1 * 1 EA
New Product
Fournisseur:
ELGA LabWater
Description:
L'Ultra se décline en 5 versions qui répondent spécifiquement aux différents besoins des laboratoires. Ultra Scientifique délivre de l'eau ultrapure en continu. Son pack de 2 cartouches assure en permanence une eau qui répond aux applications les plus exigeantes des scientifiques. Ultra Ionique répond aux exigences d'applications aussi critiques que celles de la chromatographie ou de la spectrophotométrie par l'élimination des fractions ioniques et organiques résiduelles de l'eau prétraitée. Ultra Analytic par l'intégration d'une lampe UV 185 nm, produit une eau dont le niveau de COT est exceptionnellement bas (<2 ppb). Affichage du niveau de COT en ppb. Ultra Bioscience assure la production d'une eau ultrapure apyrogène (fécondation in vitro, cultures cellulaires). Ultra Genetic intègre une lampe UV 185 nm et un module d'ultrafiltration. Affichage du niveau de COT en ppb.
Numéro de catalogue:
(PRSI3561)
Fournisseur:
ProSci Inc.
Description:
CTRP2 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI56-363)
Fournisseur:
ProSci Inc.
Description:
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
UOM:
1 * 400 µl
New Product
Fournisseur:
Thermo Fisher Scientific
Description:
The aLICator™ LIC Cloning and Expression System is designed for fast and efficient ligation independent cloning and tight regulation of gene expression in <i>E. coli</i>. The plate bacterial expression vectors are designed for high levels of target protein expression in concert with minimal basal (uninduced) expression, which permits expression of proteins that are toxic to <i>E. coli</i> cells.
Numéro de catalogue:
(734-0099)
Fournisseur:
Corning
Description:
Le collagène IV est un composant présent dans l'ensemble des membranes basales, la matrice extracellulaire sous-jacente aux cellules épithéliales et endothéliales qui entoure le muscle, la graisse et les cellules nerveuses. Il peut être utilisé comme un fin revêtement à la surface des cultures tissulaires afin d'améliorer la prolifération et la fixation des cellules et d'étudier ses effets sur le comportement cellulaire.
UOM:
1 * 1 mg
Numéro de catalogue:
(734-1098)
Fournisseur:
Corning
Description:
La laminine, l'un des principaux composants des membranes basales, est à l'origine de différentes activités biologiques, elle favorise notamment l'adhésion, la migration, la croissance et la différenciation des cellules, y compris la formation de neurites. Elle peut être utilisée comme fin revêtement des surfaces des cultures tissulaires ou comme additif soluble à un milieu de culture. Le complexe laminine/entactine haute concentration est une formulation spéciale développée pour la culture tridimensionnelle (3D).
UOM:
1 * 1 mg
Numéro de catalogue:
(J63283.QA)
Fournisseur:
Thermo Scientific
Description:
BCA Protein Assay Kit can be used to measure very dilute protein concentrations in very small sample volumes. The kit accurately measures protein concentrations from 0,5 to 30 μg/ml in tube assays and 1 to 20 μg/ml in 96- or 384-well plate assays. It is used for studying protein:protein interactions, measuring column fractions after affinity chromatography, estimating percent recovery of membrane proteins from cell extracts and high-throughput screening of fusion proteins.
UOM:
1 * 1 KIT
Numéro de catalogue:
(PRSI91-587)
Fournisseur:
ProSci Inc.
Description:
Mouse Interleukin-36 alpha(Il-36a)is a member of the IL-1 family.IL¬1 alpha,IL¬1 beta and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is expressed in many cells, including monocytes, B cells, and T cells, immune system and fetal brains. Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
UOM:
1 * 50 µG
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