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Protéines et Peptides
Numéro de catalogue:
(PRSI92-233)
Fournisseur:
ProSci Inc.
Description:
Nuclear Transcription Factor Y Subunit alpha (NFYA) is a member of the NFYA/HAP2 subunit family. NFYA founctions as a heterotrimeric transcription factor , which is composed of three components, NF-YA, NF-YB and NF-YC, binds to CCAAT motifs in the promoter regions in a variety of genes. NFYA forms a highly conserved transcription factor which stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-508)
Fournisseur:
ProSci Inc.
Description:
Mouse interleukin-16(IL-16) is a single chain non-glycosylated polypeptide. IL-16 is widely expressed in human tissues including spleen, thymus, lymph nodes, peripheral leukocytes, bone marrow and cerebellum. IL-16 plays an important role instimulating a migratory response in CD4+ lymphocytes, monocytes, and eosinophils,inducing T-lymphocyte expression of interleukin 2 receptor.It was originally identified as a CD8+ T cell-derived chemoattractant for CD4+ cells. In addition to its chemotactic properties, IL-16 has also been shown to suppress HIV-1 replication in vitro and appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. It may act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-512)
Fournisseur:
ProSci Inc.
Description:
Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alphahelix structure. IL4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL4 is primarily expressed by Th2biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-732)
Fournisseur:
ProSci Inc.
Description:
Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6751P)
Fournisseur:
ProSci Inc.
Description:
NKX2-6 peptide is used for blocking the activity of NKX2-6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4893P)
Fournisseur:
ProSci Inc.
Description:
DISP2 peptide is used for blocking the activity of DISP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4887P)
Fournisseur:
ProSci Inc.
Description:
IL-17 peptide is used for blocking the activity of IL-17 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-340)
Fournisseur:
ProSci Inc.
Description:
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-561)
Fournisseur:
ProSci Inc.
Description:
Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of the DAN family of secreted glycoproteins. DAN family antagonists are Characterised by a DAN domain that contains a cystine knot motif which is essential for binding to BMP ligands. Members of this family include DAN, gremlin, protein related to DAN and cerberus (PRDC), cerberus, sclerostin (SOST) and uterine sensitisation-associated gene 1 protein, and control diverse processes in growth, development and the cell cycle. It has also been reported that DAN family plays crucial role in early mouse embryo development by inhibiting the action of bone morphogenic proteins and modulating the action of transforming growth factor- beta superfamily members. DAN is Synthesised by small-to intermediate-sised DRG neurons and transported to the sensory nerve terminals in the skin or to the sensory nerve terminals in the dorsal horn. It has been reported that DAN is ubiquitously expressed in adult rat and human tissues. Morphological studies have revealed that, in adult rat, DAN mRNA is expressed ubiquitously in lung and brain, but not in liver.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-752)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) is also known as Decoy receptor 2 (DcR2), TNF-related apoptosis-inducing ligand receptor 4 (TRAIL receptor 4 or TRAIL-R4), CD264,which is the single-pass type I membrane protein. TNFRSF10D is receptor for the cytotoxic ligand TRAIL, which contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-749)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6975P)
Fournisseur:
ProSci Inc.
Description:
SELK peptide is used for blocking the activity of SELK antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6945P)
Fournisseur:
ProSci Inc.
Description:
DDX60 peptide is used for blocking the activity of DDX60 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5975P)
Fournisseur:
ProSci Inc.
Description:
NALP14 peptide is used for blocking the activity of NALP14 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-460)
Fournisseur:
ProSci Inc.
Description:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4685P)
Fournisseur:
ProSci Inc.
Description:
Nanos1 peptide is used for blocking the activity of Nanos1 antibody.
UOM:
1 * 50 µG
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