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Protéines et Peptides
Numéro de catalogue:
(PRSI92-637)
Fournisseur:
ProSci Inc.
Description:
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF- gamma , which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the binding and neutralizing properties of the binding proteins. The IL-18 BP isoforms b and d lack a complete Ig domain. The expression of IL-18 and the IL-18BP are unidentified in immune tissues such as the spleen, but also in nonimmune cells including keratinocytes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-661)
Fournisseur:
ProSci Inc.
Description:
Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-551)
Fournisseur:
ProSci Inc.
Description:
Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI7025P)
Fournisseur:
ProSci Inc.
Description:
CLAUDIN4 peptide is used for blocking the activity of CLAUDIN4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5403P)
Fournisseur:
ProSci Inc.
Description:
SKA2 peptide is used for blocking the activity of SKA2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5413P)
Fournisseur:
ProSci Inc.
Description:
RUSC2 peptide is used for blocking the activity of RUSC2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-958)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6847P)
Fournisseur:
ProSci Inc.
Description:
SDHD peptide is used for blocking the activity of SDHD antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4613P)
Fournisseur:
ProSci Inc.
Description:
GPAT1 peptide is used for blocking the activity of GPAT1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4593P)
Fournisseur:
ProSci Inc.
Description:
VPS53 peptide is used for blocking the activity of VPS53 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4609P)
Fournisseur:
ProSci Inc.
Description:
Rim2 peptide is used for blocking the activity of Rim2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4615P)
Fournisseur:
ProSci Inc.
Description:
UROP11 peptide is used for blocking the activity of UROP11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4677P)
Fournisseur:
ProSci Inc.
Description:
BICD2 peptide is used for blocking the activity of BICD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4703P)
Fournisseur:
ProSci Inc.
Description:
NUP155 peptide is used for blocking the activity of NUP155 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5573P)
Fournisseur:
ProSci Inc.
Description:
REEP3 peptide is used for blocking the activity of REEP3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4281P)
Fournisseur:
ProSci Inc.
Description:
ORAI1 peptide is used for blocking the activity of ADAP antibody.
UOM:
1 * 50 µG
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