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Protéines et Peptides
Numéro de catalogue:
(PRSI91-540)
Fournisseur:
ProSci Inc.
Description:
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms ( alpha, beta , gamma , and delta) with identical extracellular domains.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-546)
Fournisseur:
ProSci Inc.
Description:
Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA is produced mainly in the liver and circulates in low levels in the blood. SAA may play a role in the immune system and facilitate the repair of injured tissues, it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA also functions as an apolipoprotein of the HDL complex. The SAA cleavage product designated amyloid protein A is deposited systemically as amyloid in vital organs such as the liver, spleen, and kidneys in chronic inflammatory diseases patients. These deposits are extremely insoluble and resistant to proteolysis; they disrupt tissue structure and compromise performance.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-891)
Fournisseur:
ProSci Inc.
Description:
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4307P)
Fournisseur:
ProSci Inc.
Description:
STEAP2 peptide is used for blocking the activity of STEAP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5779P)
Fournisseur:
ProSci Inc.
Description:
C-raf peptide is used for blocking the activity of C-raf antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5769P)
Fournisseur:
ProSci Inc.
Description:
SIRT4 peptide is used for blocking the activity of SIRT4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4299P)
Fournisseur:
ProSci Inc.
Description:
PTK7 peptide is used for blocking the activity of PTK7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-468)
Fournisseur:
ProSci Inc.
Description:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI7019P)
Fournisseur:
ProSci Inc.
Description:
PHLPP1 peptide is used for blocking the activity of PHLPP1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7005P)
Fournisseur:
ProSci Inc.
Description:
ATG2B peptide is used for blocking the activity of ATG2B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-692)
Fournisseur:
ProSci Inc.
Description:
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 may have a role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-697)
Fournisseur:
ProSci Inc.
Description:
Ameloblastin (AMBN) is a member of the Ameloblastin family. AMBN is a secreted protein and is specially expressed in ameloblast, localizing to the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel Mutations of this protein may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. Ameloblastin may play an important role in the formation and mineralization of the enamel matrix. Biochemically, it is classified as an intrinsically disordered protein (IDP). Its biological role remains largely unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-686)
Fournisseur:
ProSci Inc.
Description:
Protein Kinase C and Casein Kinase Substrate in Neurons Protein 2 (PACSIN2) is a member of the PACSIN family. PACSIN2 is localized to the plasma membrane via its coiled-coil domain. PACSIN2 is widely expressed and contains one FCH domain and one SH3 domain. PACSIN2 forms homo- and hetero-aggregates with other PACSINs. PACSIN2 may play a role in vesicle formation and transport. In addition, PACSIN2 is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-696)
Fournisseur:
ProSci Inc.
Description:
Porphobilinogen Deaminase (HMBS) is a member of the HMBS family. PBGD is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. HMBS is involved in the production of heme, which is important for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. In addition, Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin. Defects in PBGD are the cause of acute intermittent porphyria.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-448)
Fournisseur:
ProSci Inc.
Description:
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause "high levels of 'bad' cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-987)
Fournisseur:
ProSci Inc.
Description:
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
UOM:
1 * 50 µG
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