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Bioss
Numéro de catalogue:
(BOSSBS-3422R-FITC)
Fournisseur:
Bioss
Description:
TCTP is involved in calcium binding and microtubule stabilization. It is an immunoglobulin E dependent histamine-releasing factor produced by lymphocytes of atopic children and present in biologic fluids of allergic patients. Both human and mouse recombinant HRF proteins caused histamine release from human basophils of a subpopulation of donors (referenced from OMIM).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7608R-CY7)
Fournisseur:
Bioss
Description:
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15414R-A680)
Fournisseur:
Bioss
Description:
HAUS3.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11130R-A350)
Fournisseur:
Bioss
Description:
Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. The KIAA1576 gene product has been provisionally designated KIAA1576 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7600R-A680)
Fournisseur:
Bioss
Description:
Target of p53/TP53 with pro-apoptotic function.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7608R-CY3)
Fournisseur:
Bioss
Description:
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3390R-A647)
Fournisseur:
Bioss
Description:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15204R-FITC)
Fournisseur:
Bioss
Description:
C5ORF42
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13027R-CY5)
Fournisseur:
Bioss
Description:
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5723R-CY5)
Fournisseur:
Bioss
Description:
Regulates the differentiation and proliferation of normal cells through the regulation of cell death.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13503R-CY3)
Fournisseur:
Bioss
Description:
Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7729R-A750)
Fournisseur:
Bioss
Description:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organisation, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7729R-A555)
Fournisseur:
Bioss
Description:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7729R-HRP)
Fournisseur:
Bioss
Description:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9898R-A680)
Fournisseur:
Bioss
Description:
Platelet receptor GI24, also known as SISP1 or PP2135, is a 311 amino acid single-pass type I membrane protein that contains one Ig-like (immunoglobulin-like) domain. GI24 is thought to contribute to tumour-invasive growth in the collagen matrix and is encoded by a gene that maps to human chromosome 10q22.1. Chromosome 10 contains over 800 genes, 135 million nucleotides and comprises nearly 4.5% of the human genome. PTEN is an important tumour suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterised by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12159R-CY3)
Fournisseur:
Bioss
Description:
May act as a calcium-activated chloride channel.
UOM:
1 * 100 µl
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