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Bioss
Numéro de catalogue:
(BOSSBS-7896R-A680)
Fournisseur:
Bioss
Description:
Stabilises the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3741R-HRP)
Fournisseur:
Bioss
Description:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1114R-A750)
Fournisseur:
Bioss
Description:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1546R-HRP)
Fournisseur:
Bioss
Description:
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8242R-A680)
Fournisseur:
Bioss
Description:
CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2), also known as HSPC058 or HSPC129, is a 466 amino acid protein that contains one FCP1 homology domain and belongs to the CTDSPL2 family. Existing as two alternatively spliced isoforms, CTDSPL2 is thought to function as a phosphatase and is encoded by a gene that maps to human chromosome 15q15.3. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localised genes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4731R-A647)
Fournisseur:
Bioss
Description:
ABP1
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11866R-CY5)
Fournisseur:
Bioss
Description:
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4611R-A750)
Fournisseur:
Bioss
Description:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4611R-CY5)
Fournisseur:
Bioss
Description:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8243R-CY3)
Fournisseur:
Bioss
Description:
The coupling of ubiquitin conjugation to endoplasmic reticulum (ER) degradation (CUE) domain functions as a ubiquitin (UB) binding domain that is approximately 40 amino acids in length. Present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways, CUE domains can bind monoubiquitin and may be required for ubiquitination of the proteins in which they are found. CUEDC1 (CUE domain-containing protein 1) is a 386 amino acid protein that contains one CUE domain, suggesting a possible role in protein trafficking and degradation pathways. Defects in the gene encoding CUEDC1 may be associated with early stage cervical cancer, implicating CUEDC1 as a potential tumor marker. Two isoforms of CUEDC1 exist due to alternative splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2787R-A750)
Fournisseur:
Bioss
Description:
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6027R-CY7)
Fournisseur:
Bioss
Description:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2787R-CY7)
Fournisseur:
Bioss
Description:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12942R-A350)
Fournisseur:
Bioss
Description:
All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0026R-A350)
Fournisseur:
Bioss
Description:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-1 and is essential in the pathway that leads to type I immunity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0074R-CY7)
Fournisseur:
Bioss
Description:
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
UOM:
1 * 100 µl
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