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ProSci Inc.
Numéro de catalogue:
(PRSI2101P)
Fournisseur:
ProSci Inc.
Description:
GPR15 peptide is used for blocking the activity of GPR15 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-029)
Fournisseur:
ProSci Inc.
Description:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-034)
Fournisseur:
ProSci Inc.
Description:
BRD2 is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-031)
Fournisseur:
ProSci Inc.
Description:
ASH2L plays a role in hematopoiesis and is associated with some special kinds of leukemia. The amount of ASH2L transcripts is extremely high in fetal liver, testis, and leukemia cell lines with erythroid and megakaryocytic potential.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-088)
Fournisseur:
ProSci Inc.
Description:
HSPB1, like the other heat shock proteins, is part of a complex system of molecular chaperones in epidermal keratinocytes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-097)
Fournisseur:
ProSci Inc.
Description:
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI45-492)
Fournisseur:
ProSci Inc.
Description:
Anti-DDC Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-490)
Fournisseur:
ProSci Inc.
Description:
Anti-DOK3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-491)
Fournisseur:
ProSci Inc.
Description:
Anti-DOK5 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-456)
Fournisseur:
ProSci Inc.
Description:
Tryptases are Trypsin-like Serine Proteases. beta -Tryptases are the main isoenzymes in mast cells. beta tryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, beta -Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, beta -Tryptases are released and participate in provoking inflammatory conditions . beta -Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-454)
Fournisseur:
ProSci Inc.
Description:
TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-458)
Fournisseur:
ProSci Inc.
Description:
The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-457)
Fournisseur:
ProSci Inc.
Description:
Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a transmembrane protein with a single Ig-like domain. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. Human TREM-1 shares 42% sequence homology with mouse TREM-1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-458)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-459)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI42-491)
Fournisseur:
ProSci Inc.
Description:
Anti-ATP1B1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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