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Numéro de catalogue: (PRSI60-295)

Fournisseur:  ProSci Inc.
Description:   For WB starting dilution is: 1:1000.
UOM:  1 * 400 µl
New Product
Numéro de catalogue: (PRSI22-756)

Fournisseur:  ProSci Inc.
Description:   Anti-BOC Rabbit Polyclonal Antibody
UOM:  1 * 50 µl
New Product
Numéro de catalogue: (PRSI15-999)

Fournisseur:  ProSci Inc.
Description:   Anti-MYH13 Rabbit Polyclonal Antibody
UOM:  1 * 50 µl
New Product
Numéro de catalogue: (PRSI61-099)

Fournisseur:  ProSci Inc.
Description:   For WB starting dilution is: 1:1000.
UOM:  1 * 400 µl
New Product
Fournisseur:  ProSci Inc.
Description:   The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIPM-4913)

Fournisseur:  ProSci Inc.
Description:   ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIPM-2347)

Fournisseur:  ProSci Inc.
Description:   DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
UOM:  1 * 1 EA

Fournisseur:  ProSci Inc.
Description:   EndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in <i>C. elegans</i>. EndoG also cleaves DNA in vitro.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIPM-2348)

Fournisseur:  ProSci Inc.
Description:   DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIPM-4673)

Fournisseur:  ProSci Inc.
Description:   MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI46-874)

Fournisseur:  ProSci Inc.
Description:   Anti-NTF3 Goat Polyclonal Antibody
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIXW-8171)

Fournisseur:  ProSci Inc.
Description:   FUNCTION: Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.
SIMILARITY: Contains 1 EGF-like domain.
INDUCTION: By phorbol 12-myristate 13-acetate (PMA).
MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
UOM:  1 * 50 µG

Fournisseur:  ProSci Inc.
Description:   FUNCTION: Rev appears to act post-transcriptionally to relieve negative repression of Gag and Env production.
PTM: Phosphoprotein whose state of phosphorylation is mediated by a specific serine kinase activity present in the nucleus. Phosphorylated at separate regions by protein kinase CK2 and MAPK. Phosphorylation by CK2 could play a role in Rev down-regulation.
SUBCELLULAR LOCATION: Nuclear; accumulates in the nucleoli.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI80-047)

Fournisseur:  ProSci Inc.
Description:   IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI45-089)

Fournisseur:  ProSci Inc.
Description:   Anti-MELK Goat Polyclonal Antibody
UOM:  1 * 1 EA
Numéro de catalogue: (PRSIXW-7913)

Fournisseur:  ProSci Inc.
Description:   FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
SUBUNIT: Homodimer; disulfide-linked.
SIMILARITY: Belongs to the stanniocalcin family.
SUBCELLULAR LOCATION: Secreted protein (Potential).
TISSUE SPECIFICITY: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood Leucocytes.
UOM:  1 * 50 µG
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