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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
For detection and measurement of mouse interleukin 12 and mouse interleukin 23 (p40) subunit.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG1, antibody against mouse IFN-gamma, APC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, FITC-conjugated.
Numéro de catalogue:
(STMC17894)
Fournisseur:
STEMCELL Technologies
Description:
Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.
UOM:
1 * 1 Kit
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Fournisseur:
STEMCELL Technologies
Description:
Column-free immunomagnetic positive selection of human CD14+ cells for HLA analysis.
Fournisseur:
STEMCELL Technologies
Description:
For detection and measurement of human interleukin 12 (p70) subunit.
Numéro de catalogue:
(STMC08000)
Fournisseur:
STEMCELL Technologies
Description:
Culture kit for derivation and proliferation of human endothelial colony-forming cells (ECFCs) and mature endothelial cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0528)
Fournisseur:
STEMCELL Technologies
Description:
Serum-free media for maturation of branching lung organoids from human ES and iPS cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0932)
Fournisseur:
STEMCELL Technologies
Description:
Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses (Dunn <i>et al.</i>; La Cava; Newman and Gonzalez-Perez). Leptin is a member of the gp130 family of cytokines and is known to be correlated with obesity (Dixit <i>et al.</i>; Dunn <i>et al.</i>). Leptin can both promote osteogenesis via osteoblast receptors and inhibit it through its actions on the hypothalamus (Figenschau <i>et al.</i>). It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase (JAK) and downstream pathways (Dunn <i>et al.</i>; Münzberg and Morrison; Newman and Gonzalez-Perez). For example, the binding of leptin to LepRb receptor activates JAK2, which leads to the phosphorylation of both JAK2 and the LepRb receptor, with three separate residues on the receptor triggering signaling pathways for SHP-2, STAT5, and STAT3 (Dunn <i>et al.</i>; Münzberg and Morrison). In addition to its effects on mature immune cells, other studies have suggested impacts on other cell types, with activities such as inducing cell proliferation and morphological differentiation in hematopoietic cell lines, chondrocytes, and hepatic cells (Figenschau <i>et al.</i>; Gainsford <i>et al.</i>; Santos-Alvarez <i>et al.</i>; Wang <i>et al.</i>).
UOM:
1 * 2 mg
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Numéro de catalogue:
(STMC100-0825)
Fournisseur:
STEMCELL Technologies
Description:
Culture medium kit for maturation of human pluripotent stem cell-derived choroid plexus organoids.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0433)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b.
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-1320)
Fournisseur:
STEMCELL Technologies
Description:
Use Interleukin 37 (IL-37) to inhibit the expression of inflammatory cytokines, such as IL-6, MIP-1α, MIP-1β, and TNF-α, in a MAPK-dependent manner (Qi <i>et al.</i>). A secreted protein belonging to the interleukin-1 cytokine family, IL-37 acts as an anti-inflammatory alarmin, with predominant expression in monocytes, and constitutive secretion by myeloid dendritic cells (Rudloff <i>et al.</i>). IL-37 has been shown to limit inflammation in human blood M1 macrophages by binding to extracellular surface receptors, requiring IL-1R8 as a coreceptor (Li <i>et al.</i>). It also has protective effects against obesity-induced inflammation and insulin resistance, reducing adipogenesis and activating AMPK signaling both in vitro and <i>in vivo</i> (Ballak <i>et al.</i>). In humans, the IL-37 gene undergoes alternative splicing, resulting in multiple isoforms of the protein (Boraschi <i>et al.</i>). For consistency and reproducibility across your applications, Interleukin 37 from STEMCELL comes lyophilised with ≥93% purity.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1330)
Fournisseur:
STEMCELL Technologies
Description:
Complement factor D is a component of the alternative pathway of the complement system and part of the innate immune system, playing a vital role in the initiation and amplification of complement activation, in order to defend against infection (Barratt and Weitz). A serine protease belonging to the S1 peptidase family, complement factor D is secreted by adipocytes into circulating blood, and is also expressed by macrophages and monocytes (White <i>et al.</i>). In the initiation phase of the complement pathway, complement factor D cleaves complement factor B (bound to component C3) to produce a complex known as C3 convertase. During the amplification phase, complement factor D cleaves complement factor B (bound to component C3b) to produce the C3bBb convertase, and is involved in the propagation of complement activation. In addition to its immunological role, complement factor D is involved in other physiological processes, such as the efficient clearing of damaged cell debris by phagocytes following acute liver injury (Cresci <i>et al.</i>). Complement factor D deficiency is associated with an increased susceptibility to pathogens like Neisseria meningitidis (Biesma <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, complement factor D from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1327)
Fournisseur:
STEMCELL Technologies
Description:
Butyrophilin 1A1 (BTN1A1) is a glycoprotein belonging to the butyrophilin (BTN) family which collectively modulates immune responses, through excitatory and inhibitory signals targeting immune cells. Butyrophilins are composed of two extracellular immunoglobulin domains and a transmembrane region, with a conserved B30.2 domain (PRYSPRY) that is present in most members (Malinowska <i>et al.</i>). BTN1A1, along with BTN2A2, has been shown to inhibit the proliferation of CD4+ and CD8+ T cells, modify T cell metabolism, and affect the expression of IL-2 and IFN-γ (Smith <i>et al.</i>). Due to these modulatory effects on T cells, BTN1A1 may have a role in inhibiting the development of autoimmune diseases (Stefferl <i>et al.</i>). BTN1A1 is also expressed in mammary glands and is required for the secretion of milk lipids during lactation (Ogg <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Fournisseur:
STEMCELL Technologies
Description:
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>). This product is animal component-free.
Numéro de catalogue:
(STMC100-1298)
Fournisseur:
STEMCELL Technologies
Description:
Use hepassocin to bind to lymphocyte-activation gene 3 (LAG-3) in an MHC class II independent manner, and inhibit antigen-specific T-cell activation (Wang <i>et al.</i>). Hepassocin is known to play a restorative role in the liver, reducing apoptosis and accelerating hepatocyte proliferation <i>in vivo</i> (Li <i>et al.</i>). In addition to these hepatoprotective effects, studies have shown that hepassocin expression is upregulated in gastric cancer tissues (Zhang <i>et al.</i>) and in breast cancer cells (Du <i>et al.</i>), suggesting it has potential to predict cancer disease progression. Hepassocin is a member of the fibrinogen superfamily, whose members share a fibrinogen domain at their C-terminus. It is predominantly expressed in the liver, and weakly in the pancreas (Hara <i>et al.</i>), and is secreted as a homodimer that consists of 312 amino acids. Hepassocin is an acute-phase reactant whose expression in HepG2 cells has been shown to be regulated by IL-6 (Liu and Ukomadu). This protein product contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, hepassocin from STEMCELL comes lyophilised with ≥87% purity, and endotoxin levels are verified to be ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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