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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human memory CD4+ T cells
Fournisseur:
STEMCELL Technologies
Description:
Complete kit for CD34+ cells from cord blood.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG2 antibody against mouse T cell receptor gamma/delta, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Interferon-gamma (IFN-γ), also known as type II interferon, is produced by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder <i>et al.</i>). IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (De Weerd and Nguyen; Krause <i>et al.</i>). IFN-γ stimulates the antimicrobial and anti-tumor activity of macrophages, NK cells, and neutrophils (Billiau and Matthys) by promoting the activation of microbial effector functions such as production of reactive oxygen species, NO intermediates, complement, etc. (Schroder <i>et al.</i>). IFN-γ enhances MHC class I and II expression in dendritic cells and mononuclear phagocytes, as well as the production of IL-12 by dendritic cells. In B cells, IFN-γ stimulates survival and growth in both mouse and human cells, and redirects B cells from proliferation towards differentiation. IFN-γ favors the development of Th1 vs Th2 cells and stimulates monocyte differentiation and function (Schroder <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human, cynomolgus, cow CD117 (c-Kit), unconjugated.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against mouse Gr-1 (Ly-6G/Ly-6C), APC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human, rhesus, sooty mangabey CD123 (IL-3Rα), unconjugated.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2a antibody against mouse CD19, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2a antibody against mouse CD62L (L-selectin), FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG1, kappa isotype control antibody, APC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG1, kappa isotype control antibody, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also known as CCL3, is a member of the CC family of chemokines and is most closely related to CCL4 or MIP-1 beta. Mouse MIP-1 alpha signal through CCR1, CCR3, CCR5, and D6 receptors (Menten <i>et al.</i>). MIP-1 alpha exhibits a variety of proinflammatory activities in vitro, including leukocyte chemotaxis, cytokine production, and mast cell activation, and it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo (Cook). MIP-1 alpha plays a critical role in macrophage recruitment into wounds and in tissue repair (DiPietro <i>et al.</i>). It has been demonstrated that blockade of the CCL3/MIP-1 alpha-CCR1 pathway blocks the recruitment of CCR1-expressing CD4+ T cells to the liver, showing a therapeutic potential for treating T cell-mediated liver diseases (Ajuebor <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg <i>et al.</i>).
Numéro de catalogue:
(STMC60140AZ)
Fournisseur:
STEMCELL Technologies
Description:
Goat polyclonal antibody against rat IgM (heavy chain), APC-conjugated.
UOM:
1 * 250 µG
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Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human SSEA-5, unconjugated.
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