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STEMCELL Technologies
Numéro de catalogue:
(STMC78108.1)
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 21 (FGF-21) is a member of the FGF family. Using β-Klotho as a cofactor, FGF-21 signals through FGF receptor 1c and 4 to activate PI3K and MAPK pathways (Mattila and Härkönen; Kharitonenkov <i>et al.</i>). FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). Upon PPAR-α stimulation FGF-21 is produced in the liver, and activation of PPAR-γ leads to FGF-21 production in adipose tissue. FGF-21 promotes insulin-independent glucose uptake and lipid accumulation in primary human adipocytes and in mouse 3T3-L1 cells. In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov and Shanafelt). FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov <i>et al.</i>).
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC17892)
Fournisseur:
STEMCELL Technologies
Description:
Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC17895)
Fournisseur:
STEMCELL Technologies
Description:
Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC10974)
Fournisseur:
STEMCELL Technologies
Description:
Serum-free and animal component-free culture supplement for expansion of human B cells.
UOM:
1 * 2 mL
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Numéro de catalogue:
(STMC100-0475)
Fournisseur:
STEMCELL Technologies
Description:
Culture medium kit for differentiation of human gastric organoids.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0934)
Fournisseur:
STEMCELL Technologies
Description:
R-Spondin-3 is a member of thrombospondin type 1 repeat (TSR-1) superfamily that is involved in the canonical Wnt/β-catenin signaling pathway (de Lau <i>et al.</i>). R-spondin proteins are characterized by two furin-like repeats at the amino terminus and thrombospondin domain located near the carboxyl terminus (de Lau <i>et al.</i>). R-spondin-3 expression is associated with ovarian cancer (Gu <i>et al.</i>), prostate cancer (Mesci <i>et al.</i>), and differentiation of intestinal epithelial cells in diabetes mellitus (Shan <i>et al.</i>). In a transgenic mice model, the expression of R-Spondin-3 induces the expansion of Lgr5+ stem cells, Paneth cells, and Lgr4+ cells, promoting the intestinal stem cell compartment (Hilkens <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain.
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-0824)
Fournisseur:
STEMCELL Technologies
Description:
Culture medium kit for establishment and maturation of human pluripotent stem cell-derived choroid plexus organoids.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0943)
Fournisseur:
STEMCELL Technologies
Description:
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>). This product is animal component-free.
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-0850)
Fournisseur:
STEMCELL Technologies
Description:
Fluorescent dyes used to label and track lysosomes in live cells - 500 tests.
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-0933)
Fournisseur:
STEMCELL Technologies
Description:
Midkine is a member of a unique family of heparin-binding growth factors that are structurally different from other fibroblast growth factors (Muramatsu; Takada <i>et al.</i>). Midkine is a proinflammatory cytokine, promoting the migration of leukocytes, fibrinolysis, and acting as a chemotactic agent towards neutrophils (Muramatsu; Said <i>et al.</i>; Takada <i>et al.</i>). It also regulates growth, differentiation, and development during the midgestion stage of embryogenesis, and promotes angiogenesis (Muramatsu; Said <i>et al.</i>; Takada <i>et al.</i>). The protein structure consists of three antiparallel β-sheets and is highly conserved between species (Muramatsu; Takada <i>et al.</i>). While the exact signal pathway is not known, proposed pathways include promoting LRP, inhibiting Src kinase, activating paxillin and STAT1α, activating PI2 and MAP kinases, suppressing caspases, binding to α6β1-integrin and tetraspanin, activating FAK, phosphorylating STAT3, suppressing STAT5 phosphorylation, activating ALK, activating PI3 kinase and transcription of NFkB, binding to neuroglycan C or nucleolin, and binding to eIF3 (Muramatsu). In cultured cells, midkine influences growth and survival of neural precursor cells, synthesis of cytokines from endothelial and renal epithelial cells, and promotes synthesis of extracellular matrices from fibroblasts (Muramatsu; Takada <i>et al.</i>).
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-1400)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with JCV (VP1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 86 peptides from major capsid protein VP1 (VP1) of the JC polyomavirus (JCV), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 354 on VP1. VP1 binds LSTc oligosaccharides found on host cell glycoproteins and glycolipids, and this interaction is said to be essential for JCV viral growth and infectivity (Neu <i>et al.</i>). The JCV VP1 (Del Valle <i>et al.</i>) and large T antigen (LT) (Delbue <i>et al.</i>) are detected in JCV-associated pathologies such as progressive multifocal leukoencephalopathy (PML) in patients with HIV. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1617)
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal antibody against mouse CD69, FITC-conjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1614)
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, PerCP-Cy5.5-conjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1334)
Fournisseur:
STEMCELL Technologies
Description:
Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn <i>et al.</i>). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui <i>et al.</i>, Schraufstatter <i>et al.</i>). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen <i>et al.</i>).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang <i>et al.</i>). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout <i>et al.</i>). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1338)
Fournisseur:
STEMCELL Technologies
Description:
A type 1 membrane glycoprotein belonging to the immunoglobulin superfamily, cluster of differentiation 200 (CD200) binds the CD200 receptor (CD200R) that is expressed on the surface of myeloid cells and T cells (Wright <i>et al.</i>), and has been shown to inhibit myeloid cell activity and macrophage cytokine production (Jenmalm <i>et al.</i>). Homologues of CD200 have been identified in viruses and can interact with CD200R to reduce macrophage pro-inflammatory cytokine production (Foster-Cuevas <i>et al.</i>). Studies have shown that the immunosuppressive effects of CD200 can promote acceptance of allogeneic tissue grafts in hosts (Gorczynski <i>et al.</i>), whereas dysregulation of CD200/CD200R can contribute to the development of autoimmune conditions, such as rheumatoid arthritis (Ren <i>et al.</i>). CD200 contains two immunoglobulin-like domains, a V-type domain and a smaller C2-type domain (Hatherley <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, cluster of differentiation 200 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein. Human recombinant CD200 at 2 μg/ml can bind human CD200R (His and hFc tag) with a linear range of 5 to 28 ng/ml, as determined by functional ELISA.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1392)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HPV16 (L1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (L1) Peptide pool is a lyophilised mixture of 124 peptides from major capsid protein L1 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 505 on L1. L1 enters the nuclei of host cells via a Kap α2β1-mediated pathway (Nelson <i>et al.</i>). It cooperates with E2, another viral protein, to enhance viral DNA replication (Siddiqa <i>et al.</i>). L1 pentamers can assemble into virus-like particles (Chen <i>et al.</i> 2000; Chen <i>et al.</i> 2001). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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