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STEMCELL Technologies
Numéro de catalogue:
(STMC100-0350)
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of mouse CD45+ TILs from single-cell suspensions of solid tumors.
UOM:
1 * 1 Kit
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Fournisseur:
STEMCELL Technologies
Description:
ARN CRISPR conçu sur mesure pour la génération d'ARN guide dans l'édition du génome CRISPR-Cas9.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human basophils.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human NK cells
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, unconjugated.
Numéro de catalogue:
(STMC100-0691)
Fournisseur:
STEMCELL Technologies
Description:
Defined supplement for improving survival of human ES and iPS cells in single-cell workflows.
UOM:
1 * 25 mL
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Numéro de catalogue:
(STMC100-0433)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b.
UOM:
1 * 1 EA
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Fournisseur:
STEMCELL Technologies
Description:
Matrix for maintenance of human ES and iPS cells in combination with TeSR™ maintenance media.
Numéro de catalogue:
(STMC100-1330)
Fournisseur:
STEMCELL Technologies
Description:
Complement factor D is a component of the alternative pathway of the complement system and part of the innate immune system, playing a vital role in the initiation and amplification of complement activation, in order to defend against infection (Barratt and Weitz). A serine protease belonging to the S1 peptidase family, complement factor D is secreted by adipocytes into circulating blood, and is also expressed by macrophages and monocytes (White <i>et al.</i>). In the initiation phase of the complement pathway, complement factor D cleaves complement factor B (bound to component C3) to produce a complex known as C3 convertase. During the amplification phase, complement factor D cleaves complement factor B (bound to component C3b) to produce the C3bBb convertase, and is involved in the propagation of complement activation. In addition to its immunological role, complement factor D is involved in other physiological processes, such as the efficient clearing of damaged cell debris by phagocytes following acute liver injury (Cresci <i>et al.</i>). Complement factor D deficiency is associated with an increased susceptibility to pathogens like Neisseria meningitidis (Biesma <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, complement factor D from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1327)
Fournisseur:
STEMCELL Technologies
Description:
Butyrophilin 1A1 (BTN1A1) is a glycoprotein belonging to the butyrophilin (BTN) family which collectively modulates immune responses, through excitatory and inhibitory signals targeting immune cells. Butyrophilins are composed of two extracellular immunoglobulin domains and a transmembrane region, with a conserved B30.2 domain (PRYSPRY) that is present in most members (Malinowska <i>et al.</i>). BTN1A1, along with BTN2A2, has been shown to inhibit the proliferation of CD4+ and CD8+ T cells, modify T cell metabolism, and affect the expression of IL-2 and IFN-γ (Smith <i>et al.</i>). Due to these modulatory effects on T cells, BTN1A1 may have a role in inhibiting the development of autoimmune diseases (Stefferl <i>et al.</i>). BTN1A1 is also expressed in mammary glands and is required for the secretion of milk lipids during lactation (Ogg <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1320)
Fournisseur:
STEMCELL Technologies
Description:
Use Interleukin 37 (IL-37) to inhibit the expression of inflammatory cytokines, such as IL-6, MIP-1α, MIP-1β, and TNF-α, in a MAPK-dependent manner (Qi <i>et al.</i>). A secreted protein belonging to the interleukin-1 cytokine family, IL-37 acts as an anti-inflammatory alarmin, with predominant expression in monocytes, and constitutive secretion by myeloid dendritic cells (Rudloff <i>et al.</i>). IL-37 has been shown to limit inflammation in human blood M1 macrophages by binding to extracellular surface receptors, requiring IL-1R8 as a coreceptor (Li <i>et al.</i>). It also has protective effects against obesity-induced inflammation and insulin resistance, reducing adipogenesis and activating AMPK signaling both in vitro and <i>in vivo</i> (Ballak <i>et al.</i>). In humans, the IL-37 gene undergoes alternative splicing, resulting in multiple isoforms of the protein (Boraschi <i>et al.</i>). For consistency and reproducibility across your applications, Interleukin 37 from STEMCELL comes lyophilised with ≥93% purity.
UOM:
1 * 1 EA
New Product
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Fournisseur:
STEMCELL Technologies
Description:
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>). This product is animal component-free.
Numéro de catalogue:
(STMC100-1298)
Fournisseur:
STEMCELL Technologies
Description:
Use hepassocin to bind to lymphocyte-activation gene 3 (LAG-3) in an MHC class II independent manner, and inhibit antigen-specific T-cell activation (Wang <i>et al.</i>). Hepassocin is known to play a restorative role in the liver, reducing apoptosis and accelerating hepatocyte proliferation <i>in vivo</i> (Li <i>et al.</i>). In addition to these hepatoprotective effects, studies have shown that hepassocin expression is upregulated in gastric cancer tissues (Zhang <i>et al.</i>) and in breast cancer cells (Du <i>et al.</i>), suggesting it has potential to predict cancer disease progression. Hepassocin is a member of the fibrinogen superfamily, whose members share a fibrinogen domain at their C-terminus. It is predominantly expressed in the liver, and weakly in the pancreas (Hara <i>et al.</i>), and is secreted as a homodimer that consists of 312 amino acids. Hepassocin is an acute-phase reactant whose expression in HepG2 cells has been shown to be regulated by IL-6 (Liu and Ukomadu). This protein product contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, hepassocin from STEMCELL comes lyophilised with ≥87% purity, and endotoxin levels are verified to be ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1332)
Fournisseur:
STEMCELL Technologies
Description:
Apolipoprotein H (apo H) has been shown to promote the coagulation of blood platelets by inhibiting thrombomodulin complex and inactivating protein C (Keeling <i>et al.</i>), but can also act as an anticoagulant by binding thrombin and inhibiting its procoagulant effects (Pozzi <i>et al.</i>). Belonging to the lipid-binding apolipoprotein family, within the lipocalin superfamily, apo H is a protein constituent of plasma, with a high affinity for negatively charged phospholipids. The structure of apo H reveals four N-terminal complement control protein (CCP) modules, also known as 'sushi' domains, and a distinct fifth C-terminal domain with four antiparallel beta sheets, two alpha-helices, and an extended loop (Schwarzenbacher <i>et al.</i>). Apo H is the main antigen implicated in antiphospholipid syndrome (APS), an autoimmune condition involving pregnancy complications and vascular thrombosis (Brusch). Studies have also reported that Apo H is involved in the progression of atherosclerosis (Harats and George). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilised with ≥93% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1397)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HPV18 (L2) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. A lyophilised mixture of 113 peptides from minor capsid protein L2 of human papillomavirus type 18 (HPV18), HPV18 (L2) peptide pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 462 on L2. With two nuclear localization signals, L2 may enter the nuclei of host cells via several import pathways mediated by Kap α2β1 heterodimers, Kap β2, and Kap β (Klucevsek <i>et al.</i>). L2 can also assemble into virus-like particles, and may have a role in encapsidation (Stauffer <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1383)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 WT reference peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 82 peptides from the spike glycoprotein of the wild-type SARS-CoV-2 virus. Consisting of the wild-type peptides that correspond to the mutated portions of the spike protein found in the SARS-CoV-2 Omicron variant (B.1.1.529), this pool is recommended to be used as a reference for the SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 mutation peptide pool. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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