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Protéines et Peptides
Fournisseur:
Merck Millipore (Calbiochem)
Description:
Native fibronectin purified from pooled bovine plasma. Effective agent for promoting attachment of cells to commonly-used culture substrates.
Numéro de catalogue:
(616424-100)
Fournisseur:
Merck Millipore (Calbiochem)
Description:
Transferrin is a serum protein involved in iron binding and transport. Native holotransferrin from human plasma.
UOM:
1 * 100 mg
Fournisseur:
Shenandoah Biotechnology
Description:
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin 1 (IL-1), interleukin 8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-gamma-activated macrophages, MIF stimulates nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α) secretion.
Fournisseur:
Shenandoah Biotechnology
Description:
Resistin-like molecule-beta (RELM-β) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-ɣ (FIZZ4). Resistin and RELM-β are the only RELM family members found in humans, whereas all four RELM family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 16 (IL-16) is produced by CD4+ and CD8+ T cells and functions as a chemoattractant for lymphocytes, monocytes, eosinophils, dendritic cells, and Langerhans cells. Additionally, IL-16 upregulates the expression of the interleukin 2 receptor (CD25), modulates T lymphocyte growth, and suppresses the replication of the human immunodeficiency virus (HIV) and simian immunodeficiency viruses (SIV).
Fournisseur:
Shenandoah Biotechnology
Description:
Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
Fournisseur:
Shenandoah Biotechnology
Description:
Prolactin is a hormone that is produced and secreted by the pituitary gland. Prolactin acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. Prolactin signal transduction occurs via JAK kinase signaling pathways. The primary function of prolactin is to regulate lactation, but prolactin also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.
Fournisseur:
Shenandoah Biotechnology
Description:
Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
Fournisseur:
Shenandoah Biotechnology
Description:
Nerve growth factor beta (β-NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. β-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. β-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat β-NGF proteins are cross-reactive.
Fournisseur:
Shenandoah Biotechnology
Description:
Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.
Fournisseur:
Shenandoah Biotechnology
Description:
Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. FGF-basic binds heparin in order to signal through fibroblast growth factor (FGF) receptor tyrosine kinases.
Fournisseur:
Shenandoah Biotechnology
Description:
Stromal cell-derived factor-1 alpha (SDF-1 α), also called CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1α signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes. Human and mouse SDF-1 α share 99% sequence identity.
Numéro de catalogue:
(734-1098)
Fournisseur:
Corning
Description:
La laminine, l'un des principaux composants des membranes basales, est à l'origine de différentes activités biologiques, elle favorise notamment l'adhésion, la migration, la croissance et la différenciation des cellules, y compris la formation de neurites. Elle peut être utilisée comme fin revêtement des surfaces des cultures tissulaires ou comme additif soluble à un milieu de culture. Le complexe laminine/entactine haute concentration est une formulation spéciale développée pour la culture tridimensionnelle (3D).
UOM:
1 * 1 mg
Numéro de catalogue:
(734-0099)
Fournisseur:
Corning
Description:
Le collagène IV est un composant présent dans l'ensemble des membranes basales, la matrice extracellulaire sous-jacente aux cellules épithéliales et endothéliales qui entoure le muscle, la graisse et les cellules nerveuses. Il peut être utilisé comme un fin revêtement à la surface des cultures tissulaires afin d'améliorer la prolifération et la fixation des cellules et d'étudier ses effets sur le comportement cellulaire.
UOM:
1 * 1 mg
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