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Antilichamen
Itemnummer:
(BOSSBS-12495R-A680)
Leverancier:
Bioss
Omschrijving:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0912R-A647)
Leverancier:
Bioss
Omschrijving:
No data available.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-11280R-A647)
Leverancier:
Bioss
Omschrijving:
The endothelin (ET) family of proteins, which includes ET-1 (endothelin-1), ET-2 (endothelin-2) and ET-3 (endothelin-3), are vasoactive peptides that are involved in various functions throughout the body. Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action. While ET-1 is a potent, 21-amino acid vasoconstrictor peptide, ET-2 has the most potent vasoconstrictor activity. ET-3 functions as a ligand for endothelin receptor type B (ETBR) and, through this interaction, mediates the maturation of enteric neurons and melanocytes. Although ET-3 is expressed as a 238 amino acid peptide, it is post-translationally modified to produce a short active isoform and a long inactive isoform. Defects in the gene encoding ET-3 are the cause of a variety of disorders, including Hirschsprung disease type 1 (HSCR1), congenital central hypoventilation syndrome (CCHS) and Waardenburg syndrome type IV (WS4).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-15309R-CY5)
Leverancier:
Bioss
Omschrijving:
C9orf115.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0912R-HRP)
Leverancier:
Bioss
Omschrijving:
No data available.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13601R-A750)
Leverancier:
Bioss
Omschrijving:
KDM2 / JHD1 is a JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2617R-A750)
Leverancier:
Bioss
Omschrijving:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-15350R-A750)
Leverancier:
Bioss
Omschrijving:
C9orf96, also known as Protein kinase-like protein SgK071, is a 680 amino acid protein that belongs to the Ser/Thr protein kinase family of the protein kinase superfamily. There are three isoforms of C9orf96 that are produced as a result of alternative splicing events. The gene encoding C9orf96 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7542R-CY5)
Leverancier:
Bioss
Omschrijving:
May be involved in vascular wall and kidney homeostasis.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7542R-A647)
Leverancier:
Bioss
Omschrijving:
May be involved in vascular wall and kidney homeostasis.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-10161R-A488)
Leverancier:
Bioss
Omschrijving:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3052R-A350)
Leverancier:
Bioss
Omschrijving:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-6508R-CY7)
Leverancier:
Bioss
Omschrijving:
BCMP11
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-10161R-CY3)
Leverancier:
Bioss
Omschrijving:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-14757R-A750)
Leverancier:
Bioss
Omschrijving:
Astroprincin.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-6508R-CY5.5)
Leverancier:
Bioss
Omschrijving:
BCMP11
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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