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Solid+Phase+Extraction
Numéro de catalogue:
(BOSSBS-11224R-FITC)
Fournisseur:
Bioss
Description:
DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7615R-A350)
Fournisseur:
Bioss
Description:
The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9301R-CY3)
Fournisseur:
Bioss
Description:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9301R-CY5.5)
Fournisseur:
Bioss
Description:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9301R-CY5)
Fournisseur:
Bioss
Description:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
UOM:
1 * 100 µl
Numéro de catalogue:
(ACRO122890010)
Fournisseur:
Thermo Scientific
Description:
Appearance: White to yellow Low melting solid or liquid after melting
UOM:
1 * 1 g
Fournisseur:
Merck
Description:
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
Fournisseur:
WATERS
Description:
Atlantis® dC18 columns are universal, silica-based, reversed phase C18 columns that are used for polar compound retention. The Atlantis® dC18 columns feature di-functionally bonded C18 ligands that have been optimised for use with highly aqueous mobile phases, including 100% water.
Fournisseur:
Thermo Scientific
Description:
Réservoir cryogénique, CryoPlus™, Canister cane storage, vapour phase; 2 ml, 4 ml, 5 ml vial and straw cane with 8 canisters, 700 ml capacity, Pour: CryoPlus 1, 2, 3, 4
Fournisseur:
Restek
Description:
This highly retentive and selective phase is developed specifically for the analysis of aldehydes and ketones as DNPH derivatives. Allure® AK is a reversed phase HPLC material that has the unique ability to separate all 13 carbonyl compounds using a simple acetonitrile/water gradient.
Fournisseur:
Merck
Description:
Chromatographie en couche mince (CCM/TLC), TLC, MS-grade, Modification de phase: Gel de silice, Matériau: Aluminium, Indicateur fluorescent: F254, Dimensions de la plaque: 50×75 mm, Épaisseur de couche: 100 µm, Taille de pore: 60 Å
Fournisseur:
Thermo Fisher Scientific
Description:
The proprietary hydrophilic bonded layer in these MAbPac SEC-1 Columns results in minimal non-desired interactions between the proteins and the stationary phase. The stationary phase is designed to handle different eluent conditions containing both high and low ionic strength mobile phases, as well as mass spectrometry friendly volatile eluents.
Fournisseur:
MACHEREY-NAGEL
Description:
Polar GC phase with optimized crosslinking for lower column bleeding and higher temperature stability
Fournisseur:
Restek
Description:
Rtx-200 columns have accomplished many difficult separations. The trifluoropropylmethyl polysiloxane stationary phase has a unique selectivity that changes elution orders and resolves compounds that phenyl, cyano, or carbowax phases can not. These columns offer exceptional thermal stability, low bleed, and superior inertness - even for active compounds such as phenols, and with sensitive detectors such as ECDs, NPDs, and MSDs.
Numéro de catalogue:
(ENZOALX270061G010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
2-tert-Butylhydroquinone
UOM:
1 * 10 g
New Product
Numéro de catalogue:
(1.07509.5000)
Fournisseur:
Merck
Description:
The PAS (periodic acid Schiff) reaction is one of the most frequently used chemical methods for histology. This Certistain® Pararosaniline (chloride) solid dye is used to prepare the Schiff’s reagent required for the PAS reaction, for the staining of mucopolysaccharides in histological tissue specimens.
As CERTISTAIN® dye it is chemically quality-certified according to highest standards and strict specifications. As an IVD product and CE registered, it can be used hassle-free in diagnostics and laboratory accreditations.
UOM:
1 * 5 kg
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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