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Solid+Phase+Extraction
Numéro de catalogue:
(BOSSBS-6941R-HRP)
Fournisseur:
Bioss
Description:
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as a E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6941R-FITC)
Fournisseur:
Bioss
Description:
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as a E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination.
UOM:
1 * 100 µl
Fournisseur:
MP Biomedicals
Description:
Circlegrow® is designed for obtaining rapid growth of <i>E. coli</i> and high yields of plasmid DNA. It extends plasmid production past log phase.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Bilobalide is a terpenoid isolated from <i>Ginkgo biloba</i>. It has been proposed to exert trophic and protective effects on neurons. It increases the sensitivity of mouse pancreatic β cells to glucose and displays protective effects during hypoxia.
Fournisseur:
Restek
Description:
Graphitised carbon black offers unique selectivity and very little adsorption for alcohol analyses. Two types of CarboBlack supports are available, CarboBlack B and CarboBlack C. CarboBlack B support, with its higher surface area, can hold up to a 10% loading of a non silicone liquid phase. CarboBlack C support can hold up to a 1% loading of a non silicone liquid phase.
Numéro de catalogue:
(PRSI29-872)
Fournisseur:
ProSci Inc.
Description:
Its gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that RNF39 plays a role in an early phase of synaptic plasticity. Its gene lies within the major histocompatibility complex class I region on chromosome 6.This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Alternative splicing results in three transcript variants encoding different isoforms.This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Alternative splicing results in three transcript variants encoding different isoforms.
UOM:
1 * 1 EA
Fournisseur:
Cayman Chemical
Description:
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
Numéro de catalogue:
(ENZOALX270061G010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
2-tert-Butylhydroquinone
UOM:
1 * 10 g
New Product
Fournisseur:
VICI JOUR RESEARCH
Description:
PEEK tubing has the strength required to withstand continuous use at HPLC pressure without swelling or bursting, and is not affected by halide salts, high strength buffers, or other aggressive mobile phases that corrode stainless steel.
Numéro de catalogue:
(ACRO122890010)
Fournisseur:
Thermo Scientific
Description:
Appearance: White to yellow Low melting solid or liquid after melting
UOM:
1 * 1 g
Fournisseur:
Thermo Scientific
Description:
Dichloro[9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene]palladium(II) Pd 12,1%, solide cristallin
Fournisseur:
Avantor Fluid Handling
Description:
Semi-open impeller design pumps solids up to 3/8" in slurries and up to 81 GPM.
Numéro de catalogue:
(TCIAE0854-5G)
Fournisseur:
TCI
Description:
Organic Standard, Ethyl Gallate, Purity (Neutralization titration): min. 98.0 %, Type de conditionnement: Flacon verre pour solides
UOM:
1 * 5 g
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