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Solid+Phase+Extraction
Numéro de catalogue:
(PRSI32-203)
Fournisseur:
ProSci Inc.
Description:
The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.
UOM:
1 * 1 EA
Numéro de catalogue:
(ICNA0290541790)
Numéro de catalogue:
(EHERCA14233050)
Fournisseur:
EHRENSTORFER GMBH
Description:
Hydroxymethyl phosphonic acid, Solide
UOM:
1 * 100 mg
Numéro de catalogue:
(BOSSBS-0362R-CY5.5)
Fournisseur:
Bioss
Description:
Protein A is a 40-60 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus (SPA). SPA binds proteins from many of mammalian species, most notably IgGs, and helps inhibit phagocytic engulfment and acts as an immunological disguise via this type of interaction, thus the bacteria will disrupts opsonization and phagocytosis. SPA is known to bind with Fc region of immunoglobulins preferentially through interaction with the VH3 variable region of the heavy chain. SPA has been shown to bind with high affinity to human IgG1 and IgG2 as well as mouse IgG2a and IgG2b, whereas bind with moderate affinity to human IgM, IgA and IgE as well as mouse IgG3 and IgG1. SPA is often produced in E. coli and is practically coupled to other molecules such as enzymes, biotin, radioactive iodine for use in immunology and other biological research. SPA is also immobilized onto solid supports such as agarose beads for total IgG purifying or interest protein or protein complex identifying in immunoprecipitation studies.
UOM:
1 * 100 µl
Fournisseur:
Avantor
Description:
Powder. For LC and molecular biology. Lot analysis on label.
Numéro de catalogue:
(613-3684)
Fournisseur:
EPPENDORF
Description:
Filtre à deux phases pour une protection optimale contre la contamination par aérosol : la couche blanche face à l'échantillon retient les gouttes, les éclaboussures et les aérosols ; la couche bleue située au-dessus forme une double barrière très efficace, qui lie de manière fiable même les biomolécules.
UOM:
1 * 960 ST
Fournisseur:
BIOCISION, LLC
Description:
TruCool® leak-proof cryogenic vials feature a screw cap with a thermally-fused gasket to ensure a tight seal. The gasket is a co-molded thermoplastic elastomer (TPE) layer, which prevents leaking, slipping and risk of contamination. The gasket is 95 kPa certified to provide a leak-proof seal. These vials are sterile and individually barcoded with a unique identifier which can be read with common barcode readers. Ideal for use in CoolRack® CF cryogenic vial modules and CoolCell® alcohol-free cell freezing containers. Recommended for use in vapor phase LN₂ only.
Numéro de catalogue:
(HONC51781-6X1L)
Fournisseur:
Honeywell Chemicals
Description:
Honeywell Chromasolv™ GC-headspace solvents:
UOM:
1 * 6 L
Fournisseur:
Agilent
Description:
These HPLC columns are made with type A silica. They are useful for many applications of acidic or neutral compounds. These columns have a higher activity level and are therefore useful for separating isomers or other compounds where silanol activity enhances selectivity.
Fournisseur:
Biotium
Description:
The antibody recognizes the hidden determinant of β-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. β-2 microglobulin is a 12 kDa protein with a pI of 5.6. Serum β2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Fournisseur:
Retsch GmbH
Description:
Robustes et puissants, les concasseurs à mâchoires ont été spécifiquement conçus pour la préparation d'échantillons durs et cassants, par lots ou en continu. Les concasseurs conviennent aux applications telles que les matériaux de construction, la minéralogie, la métallurgie, la céramique et l'analyse environnementale. L'échantillon concassé est recueilli dans un récipient collecteur amovible en acier inoxydable. Les fonctions de sécurité comprennent une trémie avec dispositif anti-projections, ainsi qu'un frein et un interrupteur de sécurité pour un arrêt immédiat lors de l'ouverture de l'appareil.
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan <i>et al.</i>). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
Numéro de catalogue:
(PRSI90-277)
Fournisseur:
ProSci Inc.
Description:
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukaemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signalling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signalling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signalling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-520)
Fournisseur:
ProSci Inc.
Description:
Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-305)
Fournisseur:
ProSci Inc.
Description:
CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI55-918)
Fournisseur:
ProSci Inc.
Description:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].
UOM:
1 * 400 µl
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