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block+heaters+
Numéro de catalogue:
(PRSI3413P)
Fournisseur:
ProSci Inc.
Description:
Anthrax peptide is used for blocking the activity of Anthrax protective antigen antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI33-467)
Fournisseur:
ProSci Inc.
Description:
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this mAb is completely blocked by the peptide used for raising this antibody. TGFa is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI79-985)
Fournisseur:
ProSci Inc.
Description:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 1 EA
Numéro de catalogue:
(AATB39062)
Fournisseur:
AAT BIOQUEST INC
Description:
Psoralen TMP Azide is an excellent building block for developing site-specific nucleic acid probes via the well-known click chemistry, i.e., Copper-Catalyzed Alkyne–Azide Cycloaddition (CuAAC).
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(AATB39063)
Fournisseur:
AAT BIOQUEST INC
Description:
Psoralen TMP Alkyne is an excellent building block for developing site-specific nucleic acid probes via the well-known click chemistry, i.e., Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC).
UOM:
1 * 1 mg
New Product
Fournisseur:
HAEP LABOR CONSULT
Description:
Thermomixers pour un ou deux blocs, adaptés aux microtubes à essai, aux tubes à centrifuger, aux cuves, aux plaques PCR, aux plaques de microtitrage et aux plaques Deep Well. Une répartition homogène de la température sur l'ensemble du bloc garantit la précision et la reproductibilité sur toute la gamme de températures. Fonction de démarrage automatique, le sens du mouvement peut être modifié via le logiciel, fonction de minuterie : de 1 min à 99,99 h ou fonctionnement continu et documentation via interface USB. Le mouvement brusque des chocs du thermomixer MHL 23 donne lieu à un transfert d'énergie mécanique à l'échantillon, ce qui est particulièrement utile pour les petites quantités.
Numéro de catalogue:
(PRSI76-227)
Fournisseur:
ProSci Inc.
Description:
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI76-325)
Fournisseur:
ProSci Inc.
Description:
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI3917P)
Fournisseur:
ProSci Inc.
Description:
Avian influenza nonstructural protein 2 peptide is used for blocking the activity of avian influenza nonstructural protein 2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI76-032)
Fournisseur:
ProSci Inc.
Description:
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30 to 33 kDa type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
UOM:
1 * 0,05 mg
New Product
Numéro de catalogue:
(PRSI79-653)
Fournisseur:
ProSci Inc.
Description:
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
UOM:
1 * 1 EA
Numéro de catalogue:
(SPCMA2305-50KGBL)
Fournisseur:
Spectrum Chemical
Description:
p-Aminophenol, also known as 4-Aminophenol, is a building block compound and can be used as a film developer.
UOM:
1 * 50 kg
Numéro de catalogue:
(PRSI76-579)
Fournisseur:
ProSci Inc.
Description:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
UOM:
1 * 0,025 mg
New Product
Numéro de catalogue:
(PRSI96-616)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3521)
Fournisseur:
ProSci Inc.
Description:
IRS-1 Antibody: Following tyrosine phosphorylation, the insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) can form a protein scaffolding for the assembly of a host of Src homology 2 (SH2) domain-containing proteins. IRS-1 tyrosine phosphorylation can occur through the activity of several cytokine and growth factor receptors such as interleukin (IL)-4, IL-9, interferon-gamma, in addition to the insulin and insulin-like growth factor 1 receptors. The scaffolding provided by IRS-1 and IRS-2 is necessary for insulin signal transduction across the cell membrane. IRS-1 tyrosine phosphorylation, and thus formation of the IRS scaffolding is inhibited by tumor necrosis factor (TNF), and this inhibition can itself be blocked by rapamycin, an inhibitor of the mammalian target of rapamycin (TOR). TNF activity could also be blocked by inhibition of the Akt kinase and the PTEN tumor suppressor, suggesting that TNF impairs insulin signaling through IRS-1 by activation of the TOR signaling pathway.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI33-425)
Fournisseur:
ProSci Inc.
Description:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Expressed in cultured epidermal, bronchial and mesothelial cells. [UniProt].
UOM:
1 * 1 EA
New Product
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