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Anticorps
Numéro de catalogue:
(ENZOADI905812100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven-transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1) receptors regulate vasoconstriction, and are expressed in vascular smooth muscle, kidney, myometrium, bladder, adipocytes, hepatocytes, platelets and testis; V1b (V3) receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus; and V2 receptors of the kidney regulate the antidiuretic effects of AVP. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI10-336)
Fournisseur:
ProSci Inc.
Description:
Anti-MILR1444A Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-313)
Fournisseur:
ProSci Inc.
Description:
Anti-LY2062430 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-296)
Fournisseur:
ProSci Inc.
Description:
Anti-ABR-214936 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-338)
Fournisseur:
ProSci Inc.
Description:
Anti-AIN457 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaMKII (calmodulin-dependent kinase II) is an enzyme which is activated by increases in intracellular Ca2+ ion concentration and it has been proposed to be pivotal in regulating synaptic strength and maturation of synapses during development. This process is thought to be critical in memory and learning and in establishing the specificity of synaptic connections. There are over two dozen alternative splice variants of CaMKII which are encoded by four genes, a, b, g, and d with apparent molecular masses of 50-60 kDa. CaMKII is widely distributed in many tissues, but is highly expressed in brain. Several studies demonstrate that CaMKII is a multifunctional enzyme which modulates the synaptic strength by binding to a subunit of NMDA receptors and promoting the phosphorylation of this NMDA receptor subunit. CaMKII also regulates DLG localization at synapses by co-localization with DLG in the same protein complex. Experimental data suggest that CaMKII is critically involved in the development of morphine tolerance as well as dependence and inhibition of this enzyme may have some therapeutic benefit in the treatment of opiate tolerance and dependence. It also has been demonstrated that d CaMKII isozyme is down-regulated in human tumor cells indicating a role for d CaMKII isozymes in cellular differentiation. Changes in d CaMKII isozyme expression pattern in human hearts during heart failure suggest that CaMKII is important for regulation of heart function. This immunoaffinity purified antibody detects proteins of 50-60 kDa, corresponding to apparent molecular mass of CaMKII isoforms on SDS-PAGE immunoblots, in samples from human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit origins. Recombinant rat calmodulin-dependent protein kinase II a subunits expressed in sf9 insect cells are also detected. As the sequences of the rat a, d, and g isoforms are conserved over this amino terminus region, this antibody is expected to recognize the d, g and a isoforms. This antibody is not expected to cross-react with the b isoform. Proteins of unknown identity, ~40, 45 and 90 kDa, may be detected on immunoblot analysis with some lysates.
Numéro de catalogue:
(ENZOADI905242100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
A member in the RIP kinase family was identified and designated RIP3 (Receptor-interacting serine/threonine protein kinase-3). RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905685100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905308100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
IL-21 is a cytokine identified in human and mouse that shows significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R) also termed NILR for novel interleukin receptor) is a member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling via the JAK-Stat pathway. IL-21 is expressed in activated T-cells, as well as HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B- and T-cell populations.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905634100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cytochrome c, which is a critical component of the electron transport chain, is a component of the functional apoptosome. Upon release from the mitochondria, cytochrome c binds to the adaptor proteins Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex. This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905165100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
HGF/SF (Hepatocyte growth factor/Scatter factor) is a multifunctional heterodimeric polypeptide. It mediates the growth and scattering of various cell types, epithelial mesenchymal transition, the formation of tubules and lumens, and promotes angiogenesis. The ligand-receptor pair has also shown to be uniquely involved in most human solid tumors and to participate in tumor development, invasion, and metastasis.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905683100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Aurora A, B, and C have emerged as key mitotic regulators of mammalian centrosome function, chromosome segregation and cytokinesis. Aurora B is one of several chromosomal passenger proteins involved in chromosome alignment at the metaphase plate and cytokinesis. Phosphorylation of a threonine residue in the Aurora activation loop (Thr232 in human Aurora B) is believed to be an essential regulatory mechanism in Aurora kinase activation.
Numéro de catalogue:
(ENZOADIKAPST211E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Extracellular regulated kinases, Erk-1 and Erk-2, both play a critical role in cellular proliferation. These extracellular kinases, are known to reside downstream of the Mitogen activated protein kinase/Extracellular protein kinases referred to as MEK. Both MEK-1 and MEK-2 phosphorylate and activate Erk on the conserved TEY motif within the activation loop of the kinase.
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