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Protéines et Peptides
Numéro de catalogue:
(PRSI92-567)
Fournisseur:
ProSci Inc.
Description:
Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulphide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4407P)
Fournisseur:
ProSci Inc.
Description:
IPR1 peptide is used for blocking the activity of IPR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4403P)
Fournisseur:
ProSci Inc.
Description:
FEZ2 peptide is used for blocking the activity of FEZ2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4425P)
Fournisseur:
ProSci Inc.
Description:
ATG16 peptide is used for blocking the activity of ATG16 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-389)
Fournisseur:
ProSci Inc.
Description:
CCL24 (eotaxin-2) has been shown to induce chemotaxis of eosinophils, basophils and resting T lymphocytes but not monocytes and activated T lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated levels of CCL24 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-387)
Fournisseur:
ProSci Inc.
Description:
CCL22 (C-C Motif Chemokine 22; Stimulated T cell chemotactic protein; STCP1) is a CC chemokine initially isolated from clones of monocyte-derived macrophages and binds to the receptor CCR4. Human CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells and thymus. It is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. May play a role in the trafficking of activated/effector T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. CCL22 has been shown to induce chemotaxis or Ca2+ mobilisation in dendritic cells, IL-2 activated NK cells and activated T lymphocytes.
UOM:
1 * 50 µG
Fournisseur:
Thermo Scientific
Description:
Colistin sulphate
Numéro de catalogue:
(PRSI91-009)
Fournisseur:
ProSci Inc.
Description:
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6187P)
Fournisseur:
ProSci Inc.
Description:
RBM35B peptide is used for blocking the activity of RBM35b antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-457)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI91-016)
Fournisseur:
ProSci Inc.
Description:
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5673P)
Fournisseur:
ProSci Inc.
Description:
ZC3H12A peptide is used for blocking the activity of ZC3H12A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1150P)
Fournisseur:
ProSci Inc.
Description:
MADD peptide is used for blocking the activity of MADD antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1148P)
Fournisseur:
ProSci Inc.
Description:
DFF45 peptide is used for blocking the activity of DFF45 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7195P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human STAT1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3559P)
Fournisseur:
ProSci Inc.
Description:
CTRP2 peptide is used for blocking the activity of the CTRP2 antibody.
UOM:
1 * 50 µG
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