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Protéines et Peptides
Numéro de catalogue:
(PRSI91-940)
Fournisseur:
ProSci Inc.
Description:
V-set and immunoglobulin domain-containing protein 4(VSIG4) is a transmembrane protein contains a signal peptide, a V-type Ig-like domain, a C2-type Ig-like domain, several potential O-glycosylation sites, and an intracellular domain with 2 potential phosphorylation sites and is structurally related to the B7 family of immune regulatory proteins. This protein is also a receptor for the complement component 3 fragments C3b and iC3b.The main function is strong negative regulator of T-cell proliferation and IL2 production and it is also potent inhibitor of the alternative complement pathway convertases. It abundantly expressed in several fetal tissues such as adult tissues, highest expression in lung and placenta and it also expressed in resting macrophages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-942)
Fournisseur:
ProSci Inc.
Description:
Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-016)
Fournisseur:
ProSci Inc.
Description:
4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-020)
Fournisseur:
ProSci Inc.
Description:
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-095)
Fournisseur:
ProSci Inc.
Description:
Cluster of Differentiation 31 (CD31) is also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils, certain tumors, and is the only known member of the CAM family on platelets. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. CD31 plays a key role in removing aged neutrophils from the body. CD31 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI4125P)
Fournisseur:
ProSci Inc.
Description:
STIM2 peptide is used for blocking the activity of STIM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4213P)
Fournisseur:
ProSci Inc.
Description:
ARF-BP1 peptide is used for blocking the activity of ARF-BP1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2125P)
Fournisseur:
ProSci Inc.
Description:
MyD88 peptide is used for blocking the activity of MyD88 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2081P)
Fournisseur:
ProSci Inc.
Description:
ARC peptide is used for blocking the activity of ARC antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2091P)
Fournisseur:
ProSci Inc.
Description:
CIDE-A peptide is used for blocking the activity of mCIDE-B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6455P)
Fournisseur:
ProSci Inc.
Description:
DBX1 peptide is used for blocking the activity of DBX1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6435P)
Fournisseur:
ProSci Inc.
Description:
TMEM59L peptide is used for blocking the activity of TMEM59L antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-547)
Fournisseur:
ProSci Inc.
Description:
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-1 (KIM-1; HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of Tim-1. One is a long (359 aa) kidney form termed Tim-1b, and one is a short (334 aa) liver form termed Tim-1a. Tim-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-004)
Fournisseur:
ProSci Inc.
Description:
At least 23 different variants of IFN- alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN- alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN- alpha subtypes differ in their sequences by only one or two positions. Naturally occurring variants also include proteins that are truncated by 10 amino acids at the carboxyl-terminal end.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-002)
Fournisseur:
ProSci Inc.
Description:
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5587P)
Fournisseur:
ProSci Inc.
Description:
CHORDC1 peptide is used for blocking the activity of CHORDC1 antibody.
UOM:
1 * 50 µG
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