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Protéines et Peptides
Numéro de catalogue:
(PRSI4701P)
Fournisseur:
ProSci Inc.
Description:
NUP107 peptide is used for blocking the activity of NUP107 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-083)
Fournisseur:
ProSci Inc.
Description:
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the “all signaling” capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-637)
Fournisseur:
ProSci Inc.
Description:
Protein S100-A9 (also MRP14 and calgranulin B)is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-087)
Fournisseur:
ProSci Inc.
Description:
Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-086)
Fournisseur:
ProSci Inc.
Description:
Bcl-2-Related Protein A1 (BCL2A1) is a member of of the BCL-2 protein family which act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. BCL2A1 is a cytoplasm protein and interacts directly with BAK1, BID, BMF and BBC3. BCL2A1 is induced by phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. BCL2A1 is invovled in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5279P)
Fournisseur:
ProSci Inc.
Description:
GALNT10 peptide is used for blocking the activity of GALNT10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6509P)
Fournisseur:
ProSci Inc.
Description:
FCHSD1 peptide is used for blocking the activity of FCHSD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-635)
Fournisseur:
ProSci Inc.
Description:
Tumour necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR (tumour necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R, as well as its paralog, EDAR, binds the ectodysplasin ligands EDA-A2 and EDA-A1, which are two alternatively spliced forms of the EDA gene. Mutations in the EDA gene are associated with the X-linked form of Hypo hidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3761P)
Fournisseur:
ProSci Inc.
Description:
LSD1 peptide is used for blocking the activity of LSD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3741P)
Fournisseur:
ProSci Inc.
Description:
TOLLIP peptide is used for blocking the activity of TOLLIP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4479P)
Fournisseur:
ProSci Inc.
Description:
Slitrk6 peptide is used for blocking the activity of Slitrk6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5581P)
Fournisseur:
ProSci Inc.
Description:
POU5F1 peptide is used for blocking the activity of POU5F1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5583P)
Fournisseur:
ProSci Inc.
Description:
SOX2 peptide is used for blocking the activity of SOX2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-079)
Fournisseur:
ProSci Inc.
Description:
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. CXCL2/MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2/MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-074)
Fournisseur:
ProSci Inc.
Description:
Human Chemokine (C-C Motif) Ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 amino acid residue signal peptide that is cleaved to generate a 99 amino acid residue mature CCL23 (amino acids 22 -120). Additional N-terminal Processing of the 99 amino acid residue variant can generate a 75 amino acid residue peptide (amino acid 46-120) that is significantly more active than the 99 amino acid residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-048)
Fournisseur:
ProSci Inc.
Description:
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.
UOM:
1 * 50 µG
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