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Protéines et Peptides
Numéro de catalogue:
(PRSI96-291)
Fournisseur:
ProSci Inc.
Description:
Fatty acid-binding protein 3 (FABP3) is also known as Heart-type fatty acid binding protein (H-FABP), Mammary-derived growth inhibitor (MDGI), Muscle fatty acid-binding protein (M-FABP), FABP11, which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. H-FABP / FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABP3 may also contribute to AS160 phosphorylation by maintaining insulin-dependent Akt activation in the cells under a lipotoxic condition.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-912)
Fournisseur:
ProSci Inc.
Description:
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-764)
Fournisseur:
ProSci Inc.
Description:
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-268)
Fournisseur:
ProSci Inc.
Description:
FasL is a cytokine that binds to Fas/TNFRSF6, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T cell mediated apoptosis and in T cell development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-198)
Fournisseur:
ProSci Inc.
Description:
Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-186)
Fournisseur:
ProSci Inc.
Description:
Annexin A5 (ANXA5) is a member of the annexin family of calcium-dependent phospholipid binding proteins. ANXA5 is an anticoagulant protein by acting as an indirect inhibitor of the thromboplastin-specific complex. ANXA5 is also a protein kinase C and phospholipase A2 inhibitor. It participate in inflammation, cellular signal transduction, growth and differentiation. ANXA5 binding to phosphatidylserine and sulfatide to regulates coagulability in the blood stream. It also protects sinsuoidal endothelial cells from ischemia reperfusion damage. ANXA5 is important for normal CFTR chloride channel activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-827)
Fournisseur:
ProSci Inc.
Description:
Trem-like transcript 2 protein (TLT2), also known as Triggering receptor expressed on myeloid cells-like protein 2, TLT2 and C6orf76, is single-pass type I membrane protein. TREML2 contains one Ig-like V-type domain, which can be induced in CD4 T-cell by concanavalin-A. As a cell surface receptor, TREML2 may play a role in the innate and adaptive immune response. TREML2 also acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. It has shown that TREML2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6325P)
Fournisseur:
ProSci Inc.
Description:
VASH1 peptide is used for blocking the activity of VASH1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6307P)
Fournisseur:
ProSci Inc.
Description:
IRF4 peptide is used for blocking the activity of IRF4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2117P)
Fournisseur:
ProSci Inc.
Description:
IKK alpha peptide is used for blocking the activity of IKK alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5643P)
Fournisseur:
ProSci Inc.
Description:
LRRC19 peptide is used for blocking the activity of LRRC19 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5655P)
Fournisseur:
ProSci Inc.
Description:
EFHD1 peptide is used for blocking the activity of EFHD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-426)
Fournisseur:
ProSci Inc.
Description:
T cells require a signal induced by the engagement of the T cell receptor and a €œcostimulatory€ signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6313P)
Fournisseur:
ProSci Inc.
Description:
ORMDL1 peptide is used for blocking the activity of ORMDL1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6367P)
Fournisseur:
ProSci Inc.
Description:
Anosmin peptide is used for blocking the activity of Anosmin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6371P)
Fournisseur:
ProSci Inc.
Description:
RASSF10 peptide is used for blocking the activity of RASSF10 antibody.
UOM:
1 * 50 µG
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