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Protéines et Peptides
Numéro de catalogue:
(PRSI5271P)
Fournisseur:
ProSci Inc.
Description:
MAK10 peptide is used for blocking the activity of MAK10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-062)
Fournisseur:
ProSci Inc.
Description:
Annexin A10 (ANXA10) contains four Annexin repeats and is a member of the Annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is reported that ANXA10 may be a clinical relevant marker for predicting outcome in both early and advanced stages of bladder cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-061)
Fournisseur:
ProSci Inc.
Description:
Methionine Aminopeptidase 1D (METAP1D) is a mitochondrion protein that belongs to the peptidase M24A family. METAP1D is overexpressed at the protein level in colon cancer cell lines and colon tumors as compared to normal tissues. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. METAP1D is also active with zinc, manganese or divalent ions. It may also play an important role in colon tumorigenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-541)
Fournisseur:
ProSci Inc.
Description:
Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-236)
Fournisseur:
ProSci Inc.
Description:
Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-042)
Fournisseur:
ProSci Inc.
Description:
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-045)
Fournisseur:
ProSci Inc.
Description:
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and beta thrombogulin ( beta TG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, beta TG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4285P)
Fournisseur:
ProSci Inc.
Description:
TDP43 peptide is used for blocking the activity of TDP43 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4287P)
Fournisseur:
ProSci Inc.
Description:
LIS1 peptide is used for blocking the activity of LIS1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6521P)
Fournisseur:
ProSci Inc.
Description:
ECRG1 peptide is used for blocking the activity of ECRG1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2245P)
Fournisseur:
ProSci Inc.
Description:
Caspase-13 peptide is used for blocking the activity of caspase-13 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-318)
Fournisseur:
ProSci Inc.
Description:
Protein FAM3D is a novel cytokine-like protein that belongs to the FAM3 family. Human FAM3D is synthesized as a 224 amino acid precursor that contains a 25 amino acid signal sequence and a 199 amino acid mature chain. FAM3D is identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3 proteins are four helix bundle cytokines with four conserved cysteines in all members (FAM3A-D). FAM3B is highly expressed in alpha and beta cells of the pancreas and is being investigated as a potential contributor to beta cell death and development of Type I Diabetes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-044)
Fournisseur:
ProSci Inc.
Description:
Human recombinant CD801 (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-376)
Fournisseur:
ProSci Inc.
Description:
Matrix metallopeptidase 9 (MMP-9) is an enzyme encoded by the MMP9 gene. This protein, which is produced by normal alveolar macrophages and granulocytes, can be activated by 4-aminophenylmercuric acetate and phorbol ester and up-regulated by ARHGEF4, SPATA13 and APC via the JNK signalling pathway in colorectal tumour cells. MMP-9 is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healling, cell migration, learning and memory, as well as in pathological processes, such as arthritis, intracerebral hemorrhage, and metastasis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-050)
Fournisseur:
ProSci Inc.
Description:
Human recombinant Bace11 (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-545)
Fournisseur:
ProSci Inc.
Description:
NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess alpha1, alpha2 and alpha3 domains, ULBP/RAET1 family members lack alpha3 domain. ULBP1 is recognised by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the immune surveillance. ULBP1 and several other family members, ULBP2 and ULBP5, own the ability to bind the human cytomegalovirus (CMV) UL16 glycoprotein. The human CMV glycoprotein UL16 binds to intracellular ULBP1 and so inhibits its expression at the cell surface, which reduces the susceptibility of the virus-infected cell to cytotoxic destruction by NK cells. The expression of ULBP1 has been found on some tumour cells and is implicated in tumour surveillance.
UOM:
1 * 50 µG
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