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Protéines et Peptides
Numéro de catalogue:
(PRSI91-887)
Fournisseur:
ProSci Inc.
Description:
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-884)
Fournisseur:
ProSci Inc.
Description:
CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48% aa sequence identity to mouse CD99.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-044)
Fournisseur:
ProSci Inc.
Description:
Cysteine Protease ATG4C (ATG4C) belongs to the peptidase C54 family. It is required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form which is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ATG4C is a cytoplasmic protein and high expressed in skeletal muscle, liver, testis and heart. ATG4C can be inhibited by N-ethylmaleimide.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-048)
Fournisseur:
ProSci Inc.
Description:
Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A) belongs to the MAP1 LC3 family. MAP1LC3A is found most abundantly in the heart, brain, liver, skeletal muscle, and testis. But it is absent in the thymus and peripheral blood leukocytes. MAP1LC3A is thought to take part in the formation of autophagosomal vacuoles and is one of the light chain subunits that functions together with both MAP1A and/or MAP1B. In addition, MAP1A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and rigidity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-052)
Fournisseur:
ProSci Inc.
Description:
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-683)
Fournisseur:
ProSci Inc.
Description:
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-682)
Fournisseur:
ProSci Inc.
Description:
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6707P)
Fournisseur:
ProSci Inc.
Description:
GBP6 peptide is used for blocking the activity of GBP6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6663P)
Fournisseur:
ProSci Inc.
Description:
CASKIN2 peptide is used for blocking the activity of CASKIN2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6673P)
Fournisseur:
ProSci Inc.
Description:
VARP peptide is used for blocking the activity of VARP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7291P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human TMEM135.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7285P)
Fournisseur:
ProSci Inc.
Description:
18 amino acids near the amino terminus of human MTERFD3.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-391)
Fournisseur:
ProSci Inc.
Description:
Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta -hexosaminidase A (HEXB). HEXB together with GM2A, catalyses the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6679P)
Fournisseur:
ProSci Inc.
Description:
MYBPC1 peptide is used for blocking the activity of MYBPC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6027P)
Fournisseur:
ProSci Inc.
Description:
MFSD2B peptide is used for blocking the activity of MFSD2B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-247)
Fournisseur:
ProSci Inc.
Description:
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
UOM:
1 * 50 µG
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