ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
P62, also known as Sequestosome I, is a 62kDa, 440 amino acid protein, initially identified as a ligand of the SH2 domain of p56lck, now known to be expressed in many tissues. In addition to TRAF6, PEST and zinc finger motifs, p62 has a C-terminal ubiquitin binding association (UBA) domain with an affinity for multi-ubiquitin chains, and it is considered to serve as a scaffold protein, capable of binding to multiple signalling molecules and uniting receptor-mediated signalling events with ubiquitinylation. Elevated levels of p62 have been reported in breast tumours and in alcoholic liver disease where p62 has been shown to be involved in the formation of Mallory bodies. Several mutations in the p62 UBA domain have been identified and the etiology of Paget’s disease of bone has been linked to one such mutation. Kuusisto and colleagues have demonstrated that p62 is also present in elevated levels in the hallmark inclusions found in various neurodegenerative conditions, including tauopathies (Alzheimer’s disease, Picks disease, and frontotemporal dementia) and synucleinopathies (Parkinson’s disease, dementia with Lewy body disease and multiple system atrophy). In recent years ubiquitin immunostaining has been used to provide adjunct information for neuropathological diagnosis, but it is becoming evident that p62 may be an even more reliable marker of neurodegenerative disease inclusion detection than tau, alpha-synuclein or ubiquitin immunostaining.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERP) is a membrane-associated ER protein strongly up-regulated by inducers of ER stress.
Numéro de catalogue:
(ENZOBMLRA1010010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Leukotriene D₄ antagonist
UOM:
1 * 10 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Nitric oxide (NO) donor.
Numéro de catalogue:
(ENZOALX480014G005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Adenosine 5'-monophosphate disodium salt (AMP disodium salt) ≥98% (par HPLC)
UOM:
1 * 5 g
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.
Fournisseur:
ENZO LIFE SCIENCES
Description:
DPPIV/DPP4 inhibitor
Numéro de catalogue:
(ENZOBMLAK5570001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
A Fluor-de-Lys® fluorescent assay system. The SIRT3 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human SIRT3 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOBMLAK5110001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The HDAC1 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC1 included in the kit.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOENZABS2270100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry, WB, FUNC
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2190100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, ICC, IHC, WB
Species reactivity: Mammalian
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOENZABS2260100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, IP, WB
Species reactivity: Human, Mouse
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2440100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS1580100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2460100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l' est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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