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ProSci Inc.
Numéro de catalogue:
(PRSI31-322)
Fournisseur:
ProSci Inc.
Description:
The specific function of this protein remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-330)
Fournisseur:
ProSci Inc.
Description:
The specific function of this protein remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-455)
Fournisseur:
ProSci Inc.
Description:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5409)
Fournisseur:
ProSci Inc.
Description:
RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases I kappa Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha -induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of I kappa Beta increased stability. RSUME-enhanced sumoylation of I kappa Beta leads to the inhibition of NF-kappa Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5411)
Fournisseur:
ProSci Inc.
Description:
RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with I kappa B kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kappa B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa B activation pathway.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5445)
Fournisseur:
ProSci Inc.
Description:
Mimitin Antibody: Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5439)
Fournisseur:
ProSci Inc.
Description:
GOLPH1 Antibody: GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintenance of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-464)
Fournisseur:
ProSci Inc.
Description:
LOC346157 is a new candidate transcription factor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-451)
Fournisseur:
ProSci Inc.
Description:
FOXA3 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5731P)
Fournisseur:
ProSci Inc.
Description:
APC7 peptide is used for blocking the activity of APC7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5747P)
Fournisseur:
ProSci Inc.
Description:
PIAS4 peptide is used for blocking the activity of PIAS4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXP-5132)
Fournisseur:
ProSci Inc.
Description:
Anti-FGF16 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-168)
Fournisseur:
ProSci Inc.
Description:
ZMYND11 was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-159)
Fournisseur:
ProSci Inc.
Description:
RCOR2 may act as a component of a corepressor complex that represses transcription.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-184)
Fournisseur:
ProSci Inc.
Description:
TRIM34 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mappped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternate splicing of this gene generates four transcript variants. Additionally, a read-through transcript transcribed from this gene and TRIM6 has been observed.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-493)
Fournisseur:
ProSci Inc.
Description:
Anti-AdV Mouse Monoclonal Antibody
UOM:
1 * 1 EA
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