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ProSci Inc.
Numéro de catalogue:
(PRSI79-221)
Fournisseur:
ProSci Inc.
Description:
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-194)
Fournisseur:
ProSci Inc.
Description:
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI43-069)
Fournisseur:
ProSci Inc.
Description:
Anti-NLGN4X Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI43-078)
Fournisseur:
ProSci Inc.
Description:
Anti-FBL Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3013)
Fournisseur:
ProSci Inc.
Description:
CARD10 Antibody: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10. This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kappa B. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the I kappa K complex, demonstrating its importance in the regulation of NF-kappa B transcription factor activation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3027)
Fournisseur:
ProSci Inc.
Description:
NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1 beta -processing activity and is thought to function as a modulator of NF-kappa B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3029)
Fournisseur:
ProSci Inc.
Description:
Bmf Antibody: Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-223)
Fournisseur:
ProSci Inc.
Description:
The exact function of this protein remains unknown
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-225)
Fournisseur:
ProSci Inc.
Description:
KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI38-154)
Fournisseur:
ProSci Inc.
Description:
IGF-BP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFB-P5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGF-BP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI38-171)
Fournisseur:
ProSci Inc.
Description:
Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions. Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI38-174)
Fournisseur:
ProSci Inc.
Description:
Interleukin 31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI38-166)
Fournisseur:
ProSci Inc.
Description:
Anti-MIA Rabbit Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-152)
Fournisseur:
ProSci Inc.
Description:
Anti-SPP1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-156)
Fournisseur:
ProSci Inc.
Description:
Anti-SYK Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-153)
Fournisseur:
ProSci Inc.
Description:
Anti-STAT3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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