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ProSci Inc.
Numéro de catalogue:
(PRSI79-162)
Fournisseur:
ProSci Inc.
Description:
Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-180)
Fournisseur:
ProSci Inc.
Description:
Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI70-850)
Fournisseur:
ProSci Inc.
Description:
Anti-DNASE1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
Numéro de catalogue:
(PRSI70-893)
Fournisseur:
ProSci Inc.
Description:
Anti-Red Blood Cells Rabbit Polyclonal Antibody
UOM:
1 * 250 µl
Numéro de catalogue:
(PRSI79-203)
Fournisseur:
ProSci Inc.
Description:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI70-905)
Fournisseur:
ProSci Inc.
Description:
Anti-UBC Rabbit Polyclonal Antibody
UOM:
1 * 200 µl
Numéro de catalogue:
(PRSI70-909)
Fournisseur:
ProSci Inc.
Description:
Anti-GNAO1 Rabbit Polyclonal Antibody
UOM:
1 * 250 µl
Numéro de catalogue:
(PRSI79-264)
Fournisseur:
ProSci Inc.
Description:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-247)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI70-301)
Fournisseur:
ProSci Inc.
Description:
Anti-CBR1 Mouse Monoclonal Antibody
UOM:
1 * 0,5 µl
Numéro de catalogue:
(PRSI70-963)
Fournisseur:
ProSci Inc.
Description:
Anti-PARP1 Rabbit Polyclonal Antibody
UOM:
1 * 250 µl
Numéro de catalogue:
(PRSI70-985)
Fournisseur:
ProSci Inc.
Description:
Anti-ID3 Rabbit Polyclonal Antibody
UOM:
1 * 250 µl
Numéro de catalogue:
(PRSI79-285)
Fournisseur:
ProSci Inc.
Description:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-287)
Fournisseur:
ProSci Inc.
Description:
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-291)
Fournisseur:
ProSci Inc.
Description:
STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe, 2 variant cDNAs were identified, which were termed STAT6B and STAT6C, encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain, respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6, but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression, and is not tyrosine phosphorylated
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-299)
Fournisseur:
ProSci Inc.
Description:
BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
UOM:
1 * 1 EA
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