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ProSci Inc.
Numéro de catalogue:
(PRSI70-923)
Fournisseur:
ProSci Inc.
Description:
Anti-CD19 Rabbit Polyclonal Antibody
UOM:
1 * 200 µl
Numéro de catalogue:
(PRSI79-198)
Fournisseur:
ProSci Inc.
Description:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-202)
Fournisseur:
ProSci Inc.
Description:
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-227)
Fournisseur:
ProSci Inc.
Description:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-200)
Fournisseur:
ProSci Inc.
Description:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-208)
Fournisseur:
ProSci Inc.
Description:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-216)
Fournisseur:
ProSci Inc.
Description:
Involved in stress resistance and actin organization.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-195)
Fournisseur:
ProSci Inc.
Description:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6391)
Fournisseur:
ProSci Inc.
Description:
AP3S1 Antibody: AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3 is an heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). AP3S1 Interacts with AGAP1 and may play an important role in carcinoma.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI30-199)
Fournisseur:
ProSci Inc.
Description:
FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It plays a possible role in transfer of immunoglobulin G from mother to fetus.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-100)
Fournisseur:
ProSci Inc.
Description:
Anti-GGCX Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-101)
Fournisseur:
ProSci Inc.
Description:
Anti-TMPRSS11D Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-099)
Fournisseur:
ProSci Inc.
Description:
Anti-WNT9B Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-911)
Fournisseur:
ProSci Inc.
Description:
Anti-MTMR1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-276)
Fournisseur:
ProSci Inc.
Description:
EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.
Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-406)
Fournisseur:
ProSci Inc.
Description:
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initially Synthesised in the liver. The light and heavy chains are linked together by disulfide bonds. The light chain contains a Gla and two EGF-like domains. The heavy chain corresponds to the serine protease domain. It can form a heterodimer with SERPINA5.
UOM:
1 * 50 µG
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