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ProSci Inc.
Numéro de catalogue:
(PRSI3885)
Fournisseur:
ProSci Inc.
Description:
PAK2 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-540)
Fournisseur:
ProSci Inc.
Description:
Kin is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by the human ortholog.The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4633P)
Fournisseur:
ProSci Inc.
Description:
SAPAP4 peptide is used for blocking the activity of SAPAP4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-772)
Fournisseur:
ProSci Inc.
Description:
ELF4 contains 1 ETS DNA-binding domain and belongs to the ETS family. It is transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. It transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. It acts synergistically with RUNX1 to transactivate the IL3 promoter and also transactivates the PRF1 promoter in natural killer (NK) cells. ELF4 plays a role in the development and function of NK and NK T-cells and in innate immunity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-765)
Fournisseur:
ProSci Inc.
Description:
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-764)
Fournisseur:
ProSci Inc.
Description:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-κ-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-771)
Fournisseur:
ProSci Inc.
Description:
May associate with CD21. May regulate the release of Ca2+ from intracellular stores.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-766)
Fournisseur:
ProSci Inc.
Description:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7356)
Fournisseur:
ProSci Inc.
Description:
Latexin protein. Strongly similar to rat latexin (TCI, Rn.11404); may be a tissue carboxypeptidase inhibitor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-7340)
Fournisseur:
ProSci Inc.
Description:
Leptin; leptin (murine obesity homolog); obesity. Leptin, a product of the Obese (ob) gene, is a ligand for the OB receptor (OC-R). Mice with mutations of the ob gene have been found to be obese and diabetic and to have reduced activity, metabolism, and body temperature. M.W: 16,000.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-295)
Fournisseur:
ProSci Inc.
Description:
ZNF221 may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI46-366)
Fournisseur:
ProSci Inc.
Description:
Anti-SH2D1A Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-383)
Fournisseur:
ProSci Inc.
Description:
Anti-SMAD9 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-997)
Fournisseur:
ProSci Inc.
Description:
Anti-AGAP2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-118)
Fournisseur:
ProSci Inc.
Description:
KLHL25 is also known as ENC2. It is a BTB/POZ KELCH domain protein
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-488)
Fournisseur:
ProSci Inc.
Description:
Anti-AdV Mouse Monoclonal Antibody
UOM:
1 * 1 EA
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