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Numéro de catalogue:
(PRSI92-279)
Fournisseur:
ProSci Inc.
Description:
Heat shock protein beta-2(HSPB2) is a protein that in humans is encoded by the HSPB2 gene. HSPB2 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. It is expressed preferentially in the heart and skeletal muscle. HSPB2 has been shown to interact with TRAF6, HSPB8, Myotonic dystrophy protein kinase and CRYAB. HSPB2 regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-287)
Fournisseur:
ProSci Inc.
Description:
Protachykinin-1(TAC1) is a secreted protein and belongs to the tachykinin family. TAC1 is encoded by the TAC1 gene. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-288)
Fournisseur:
ProSci Inc.
Description:
Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. It is possible major paracrine effector of normal epithelial cell proliferation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-399)
Fournisseur:
ProSci Inc.
Description:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-381)
Fournisseur:
ProSci Inc.
Description:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-901)
Fournisseur:
ProSci Inc.
Description:
Anti-SOX9A Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3126)
Fournisseur:
ProSci Inc.
Description:
KHK encodes the gene ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The splice variant presented encodes the highly active form found in liver, renal cortex, and small intestine, while the alternate variant encodes the lower activity form found in most other tissues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3139)
Fournisseur:
ProSci Inc.
Description:
Strongly similar to rat latexin (TCI, Rn.11404); may be a tissue carboxypeptidase inhibitor.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3204)
Fournisseur:
ProSci Inc.
Description:
This protein is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4003)
Fournisseur:
ProSci Inc.
Description:
APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-004)
Fournisseur:
ProSci Inc.
Description:
NKIRAS1 is an atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. NKIRAS1 may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-001)
Fournisseur:
ProSci Inc.
Description:
SSBP3 may be involved in transcription regulation of the alpha 2 (I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-997)
Fournisseur:
ProSci Inc.
Description:
The function of C2orf25 remains unknown.Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to adenosylcobalamin in mitochondria and to methylcobalamin in cytoplasm is necessary for homeostasis of methylmalonic acid and homocysteine. C2ORF25 encodes a protein involved in an early step of cobalamin metabolism (Coelho et al., 2008 [PubMed 18385497]).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-010)
Fournisseur:
ProSci Inc.
Description:
The exact function of C11orf67 remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-276)
Fournisseur:
ProSci Inc.
Description:
EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.
Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-406)
Fournisseur:
ProSci Inc.
Description:
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initially Synthesised in the liver. The light and heavy chains are linked together by disulfide bonds. The light chain contains a Gla and two EGF-like domains. The heavy chain corresponds to the serine protease domain. It can form a heterodimer with SERPINA5.
UOM:
1 * 50 µG
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